OCT3 mediates renal clearance of organic cations

Stable Identifier
R-HSA-549304
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

The human gene SLC22A3 encodes organic cation transporter OCT3. It is mainly expressed in skeletal muscle, liver, placenta, kidney and heart, and to a lesser extent in brain. OCT3 is involved in the biliary excretion of cationic drugs. In CNS, ganglia and heart, OCT3 regulates the interstitial concentrations of monoamine neurotransmitters and cationic drugs. In placenta, OCT3 is responsible for the release of acetylcholine during nonneuronal cholinergic regulation (Grundemann D et al,1998; Wu X et al, 2000).

Literature References
PubMed ID Title Journal Year
10196521 Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter

Gründemann, D, Schechinger, B, Rappold, GA, Schömig, E

Nat Neurosci 1998
10966924 Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney

Wu, X, Huang, W, Ganapathy, ME, Wang, H, Kekuda, R, Conway, SJ, Leibach, FH, Ganapathy, V

Am J Physiol Renal Physiol 2000
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
organic cation transmembrane transporter activity of SLC22A3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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