Reactome: A Curated Pathway Database

CRY proteins stabilize unphosphorylated BMAL1:CLOCK,NPAS2

Stable Identifier
R-HSA-549355
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CRY1 and CRY2 bind the unphosphorylated BMAL1:CLOCK (ARNTL:CLOCK) heterodimer (and by homology the BMAL1:NPAS2 (ARNTL:NPAS2) heterodimer) and prolong its half-life. The unphosphorylated BMAL1:CLOCK heterodimer only weakly activates transcription and is therefore believed to competitively reduce transcription by phosphorylated BMAL1:CLOCK heterodimer. The complex of unphosphorylated BMAL1:CLOCK with CRY may contain additional components and may traffic into the nucleus.

Participants
Participant Of
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Inferred From