Reactome | Expression of NR1D1 (REV-ERBA)

Expression of NR1D1 (REV-ERBA)

Stable Identifier

R-HSA-549475

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

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The NR1D1 (REV-ERBA) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. In mouse the Rev-erba gene shows circadian expression due to transactivation by the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer. REV-ERBA binds the promoter of its own gene and represses its own expression (Adelmont et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
2539258	Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus Miyajima, N, Horiuchi, R, Shibuya, Y, Fukushige, S, Matsubara, K, Toyoshima, K, Yamamoto, T	Cell	1989
8622974	A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity Adelmant, G, Bègue, A, Stéhelin, D, Laudet, V	Proc Natl Acad Sci U S A	1996