Expression of NR1D1 (REV-ERBA)

Stable Identifier
R-HSA-549475
Type
Reaction [omitted]
Species
Homo sapiens
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The NR1D1 (REV-ERBA) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. In mouse the Rev-erba gene shows circadian expression due to transactivation by the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer. REV-ERBA binds the promoter of its own gene and represses its own expression (Adelmont et al. 1996).

Literature References
PubMed ID Title Journal Year
2539258 Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus

Miyajima, N, Horiuchi, R, Shibuya, Y, Fukushige, S, Matsubara, K, Toyoshima, K, Yamamoto, T

Cell 1989
8622974 A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity

Adelmant, G, Bègue, A, Stéhelin, D, Laudet, V

Proc Natl Acad Sci U S A 1996
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