Expression of NR1D1 (REV-ERBA)

Stable Identifier
R-HSA-549475
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NRID1 gene produces NRID1
ReviewStatus
5/5
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Expression of NR1D1 (REV-ERBA)
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The NR1D1 (REV-ERBA) gene is transcribed to yield mRNA and the mRNA is translated to yield NR1D1 protein (Miyajima et al. 1989, Adelmant et al. 1996, also inferred from mouse homologs). In mouse the Rev-erba gene shows circadian expression due to transactivation by the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer. REV-ERBA binds the promoter of its own gene and represses its own expression (Adelmant et al. 1996). Activation of NR1D1 (REV-ERBA) expression by phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) is inferred from mouse. NPAS2 is predicted to act redundantly with CLOCK. As inferred from mouse, RORA binds RRE DNA elements and recruits the coactivators PGC-1alpha (PPARGC1A) and p300 (EP300, a histone acetylase). RORA binds the NR1D1 (REV-ERBA) promoter and activates transcription.
Literature References
PubMed ID Title Journal Year
8622974 A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity

Stéhelin, D, Adelmant, G, Laudet, V, Bègue, A

Proc Natl Acad Sci U S A 1996
2539258 Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus

Yamamoto, T, Miyajima, N, Fukushige, S, Matsubara, K, Toyoshima, K, Horiuchi, R, Shibuya, Y

Cell 1989
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
NR1D1:heme:Corepressors:NR1D1 gene [nucleoplasm] (Homo sapiens)
Positively by
Regulator
RORA:Coactivator:NR1D1 gene [nucleoplasm] (Homo sapiens)
Regulator
p-BMAL1:p-CLOCK,NPAS2:NR1D1 gene [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Nr1d1 (Rev-erba) (Mus musculus)
Authored
May, B  (2010-03-19)
Reviewed
Somers, J  (2021-01-23)
Delaunay, F  (2010-06-23)
Hirota, T  (2010-06-23)
Kay, SA  (2010-06-23)
Albrecht, U  (2010-06-23)
D'Eustachio, P  (2009-05-27)
Created
May, B  (2010-03-21)
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