Reactome | Expression of PERIOD-1

Expression of PERIOD-1

Stable Identifier

R-HSA-549533

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

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The PERIOD-1 (PER1) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. The promoter of the PER1 gene contains E-boxes which are bound by the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer (and probably also the BMAL1:NPAS2 (ARNTL:NPAS2) heterodimer). The BMAL1:CLOCK heterodimer activates transcription of PER1.

Literature References

PubMed ID	Title	Journal	Year
9427249	Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei Shearman, LP, Zylka, MJ, Weaver, DR, Kolakowski LF, Jr, Reppert, SM	Neuron	1997
9333243	Circadian oscillation of a mammalian homologue of the Drosophila period gene Tei, H, Okamura, H, Shigeyoshi, Y, Fukuhara, C, Ozawa, R, Hirose, M, Sakaki, Y	Nature	1997
14750904	Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts Miyazaki, K, Nagase, T, Mesaki, M, Narukawa, J, Ohara, O, Ishida, N	Biochem J	2004
17994337	Activation of human period-1 by PKA or CLOCK/BMAL1 is conferred by separate signal transduction pathways Motzkus, D, Loumi, S, Cadenas, C, Vinson, C, Forssmann, WG, Maronde, E	Chronobiol Int	2007