The PERIOD-1 (PER1) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. The promoter of the PER1 gene contains E-boxes which are bound by the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer (and probably also the BMAL1:NPAS2 (ARNTL:NPAS2) heterodimer). The BMAL1:CLOCK heterodimer activates transcription of PER1.
Shearman, LP, Zylka, MJ, Weaver, DR, Kolakowski LF, Jr, Reppert, SM
Tei, H, Okamura, H, Shigeyoshi, Y, Fukuhara, C, Ozawa, R, Hirose, M, Sakaki, Y
Miyazaki, K, Nagase, T, Mesaki, M, Narukawa, J, Ohara, O, Ishida, N
Motzkus, D, Loumi, S, Cadenas, C, Vinson, C, Forssmann, WG, Maronde, E
© 2021 Reactome