Reactome | GNAQ [plasma membrane]

GNAQ [plasma membrane]

Stable Identifier

R-HSA-55453

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Guanine nucleotide-binding protein G(q), alpha subunit

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Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Signal amplification (Homo sapiens)
    - ADP signalling through P2Y purinoceptor 1 (Homo sapiens)
      - Activated P2Y purinoceptor 1 binds G-protein Gq (Homo sapiens)
        
        ADP:P2RY1:G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
      - Dissociation of the P2Y purinoceptor 1:Gq complex (Homo sapiens)
        
        ADP:P2RY1:G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
      - Gq activation by P2Y purinoceptor 1 (Homo sapiens)
        
        ADP:P2RY1:G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
        
        ADP:P2RY1:G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
      - P2Y purinoceptor 1 activates MAP kinase p38 alpha (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
    - Thromboxane signalling through TP receptor (Homo sapiens)
      - Activated TP receptor binds G-proten Gq (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
      - Dissociation of the TP:Gq complex (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
      - Gq activation by TP receptor (Homo sapiens)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
  - Thrombin signalling through proteinase activated receptors (PARs) (Homo sapiens)
    - Dissociation of the PAR:Gq complex (Homo sapiens)
      - G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
    - Gq activation by PAR (Homo sapiens)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
      - Thrombin-activated PAR:Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
    - Thrombin-activated PAR binds G-protein Gq (Homo sapiens)
      - Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
      - Thrombin-activated PAR:Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P50148 GNAQ

Gene Names

GNAQ, GAQ

Chain

chain:1-359

Reference Genes

BioGPS Gene:2776 GNAQ

COSMIC (genes):GNAQ GNAQ

CTD Gene:2776 GNAQ

dbSNP Gene:2776 GNAQ

ENSEMBL:ENSG00000156052 GNAQ

HGNC:4390 GNAQ

KEGG Gene (Homo sapiens):2776 GNAQ

Monarch:2776 GNAQ

NCBI Gene:2776 GNAQ

OMIM:600998 GNAQ

UCSC:P50148 GNAQ

Reference Transcript

RefSeq:NM_002072.4 GNAQ

Other Identifiers

0004280671

11733108_at

11749927_a_at

11756067_a_at

11759093_s_at

11759094_a_at

11759095_at

11759096_at

17095111

202615_at

211426_x_at

224861_at

224862_at

224863_at

2576509

2576510

2576512

2576513

2576515

2576516

2576518

2576520

2576521

2576523

2576524

2776

3210813

3210814

3210815

3210816

3210817

3210818

3210819

3210820

3210821

3210824

3210846

3210847

3210854

3210884

3210918

3210919

38580_at

38581_at

49011_at

63890_f_at

8161906

8180344

91559_at

A_23_P136693

A_24_P303852

A_32_P228124

A_33_P3343155

GE61675

GE81110

GO:0000166

GO:0001508

GO:0001664

GO:0001750

GO:0003674

GO:0003924

GO:0005096

GO:0005515

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005635

GO:0005737

GO:0005764

GO:0005765

GO:0005773

GO:0005794

GO:0005834

GO:0005886

GO:0005929

GO:0006464

GO:0006469

GO:0006950

GO:0007165

GO:0007186

GO:0007188

GO:0007189

GO:0007202

GO:0007213

GO:0007215

GO:0007267

GO:0007596

GO:0007603

GO:0008150

GO:0009649

GO:0016020

GO:0019001

GO:0030168

GO:0030234

GO:0031683

GO:0031826

GO:0031965

GO:0032991

GO:0043167

GO:0043226

GO:0043547

GO:0045202

GO:0046872

GO:0050821

GO:0060828

GO:0070062

Hs.296261.0.S3_3p_at

Hs.5437.3.A1_3p_at

Hs.5437.3.A2_3p_at

Hs.5437.3.A3_3p_at

ILMN_1659923

ILMN_1741482

PH_hs_0033992

TC09001228.hg

U40038_at

U43083_at

g1181670_3p_a_at

g1181670_3p_x_at

Participant Of

hasMember

G-protein alpha (q/11) [plasma membrane]

hasCandidate

G(q) alpha 11,14,15,Q [plasma membrane]

Inferred To

gpa2 [plasma membrane] (Schizosaccharomyces pombe)

gpaC [plasma membrane] (Dictyostelium discoideum)

gnaq [plasma membrane] (Danio rerio)

gnaq [plasma membrane] (Xenopus tropicalis)

gpaJ [plasma membrane] (Dictyostelium discoideum)

gpaF [plasma membrane] (Dictyostelium discoideum)

GPA1 [plasma membrane] (Saccharomyces cerevisiae)

gpaI [plasma membrane] (Dictyostelium discoideum)

gpaA [plasma membrane] (Dictyostelium discoideum)

gpaG [plasma membrane] (Dictyostelium discoideum)

gbqA [plasma membrane] (Dictyostelium discoideum)

gpaD [plasma membrane] (Dictyostelium discoideum)

GPA2 [plasma membrane] (Saccharomyces cerevisiae)

gpaH [plasma membrane] (Dictyostelium discoideum)

gpaE [plasma membrane] (Dictyostelium discoideum)

Homologues of GNA11 [plasma membrane] (Dictyostelium discoideum)

Homologues of GNA11 [plasma membrane] (Saccharomyces cerevisiae)

Homologues of GNA11 [plasma membrane] (Schizosaccharomyces pombe)

gpa-5 [plasma membrane] (Caenorhabditis elegans)

gpaL [plasma membrane] (Dictyostelium discoideum)

gpaB [plasma membrane] (Dictyostelium discoideum)

gpa1 [plasma membrane] (Schizosaccharomyces pombe)

Gnaq [plasma membrane] (Mus musculus)

Gnaq [plasma membrane] (Rattus norvegicus)

GNAQ [plasma membrane] (Bos taurus)

GNAQ [plasma membrane] (Gallus gallus)

gpaK [plasma membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_002063.2

OpenTargets

ENSG00000156052

HPA

ENSG00000156052-GNAQ

GeneCards

P50148

Ensembl

ENST00000286548, ENSG00000156052, ENSP00000286548

PRO

P50148

Orphanet

22147

PDB

6VU5

HMDB Protein

HMDBP02022

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10276 RARA	3	SUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) RARA [nucleoplasm] (R-HSA-446164)	0.591	4
UniProt:P49407 ARRB1	5	PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [cytosol] (R-HSA-264470) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.524	2

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