Reactome | GNAQ [plasma membrane]

GNAQ [plasma membrane]

Stable Identifier

R-HSA-55453

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Guanine nucleotide-binding protein G(q), alpha subunit

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Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Signal amplification (Homo sapiens)
    - ADP signalling through P2Y purinoceptor 1 (Homo sapiens)
      - Activated P2Y purinoceptor 1 binds G-protein Gq (Homo sapiens)
        
        ADP:P2RY1:G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
      - Dissociation of the P2Y purinoceptor 1:Gq complex (Homo sapiens)
        
        ADP:P2RY1:G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
      - Gq activation by P2Y purinoceptor 1 (Homo sapiens)
        
        ADP:P2RY1:G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
        
        ADP:P2RY1:G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
      - P2Y purinoceptor 1 activates MAP kinase p38 alpha (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
    - Thromboxane signalling through TP receptor (Homo sapiens)
      - Activated TP receptor binds G-proten Gq (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
      - Dissociation of the TP:Gq complex (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
      - Gq activation by TP receptor (Homo sapiens)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
  - Thrombin signalling through proteinase activated receptors (PARs) (Homo sapiens)
    - Thrombin-activated PARs activate Gq (Homo sapiens)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
      - Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
    - Thrombin-activated PARs binds G-protein Gq (Homo sapiens)
      - Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
      - Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
    - Thrombin-activated PARs:Gq (active) dissociate (Homo sapiens)
      - G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNAQ [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P50148 GNAQ

Gene Names

GNAQ, GAQ

Chain

chain:1-359

Reference Genes

BioGPS Gene:2776 GNAQ

COSMIC (genes):GNAQ GNAQ

CTD Gene:2776 GNAQ

dbSNP Gene:2776 GNAQ

ENSEMBL:ENSG00000156052 GNAQ

HGNC:4390 GNAQ

KEGG:hsa:2776 GNAQ

Monarch:2776 GNAQ

NCBI Gene:2776 GNAQ

OMIM:600998 GNAQ

UCSC:P50148 GNAQ

Reference Transcript

RefSeq:NM_002072.4 GNAQ

Other Identifiers

11733108_at

11749927_a_at

11756067_a_at

11759093_s_at

11759094_a_at

11759095_at

11759096_at

17095111

202615_PM_at

202615_at

211426_PM_x_at

211426_x_at

224861_PM_at

224861_at

224862_PM_at

224862_at

224863_PM_at

224863_at

2576509

2576510

2576512

2576513

2576515

2576516

2576518

2576520

2576521

2576523

2576524

2776

3210813

3210814

3210815

3210816

3210817

3210818

3210819

3210820

3210821

3210824

3210846

3210847

3210854

3210884

3210917

3210918

3210919

38580_at

38581_at

49011_at

63890_f_at

8161906

8180344

91559_at

A_23_P136693

A_24_P303852

A_32_P228124

A_33_P3343155

GE61675

GE81110

GO:0001508

GO:0001664

GO:0001750

GO:0003824

GO:0003924

GO:0003925

GO:0005096

GO:0005515

GO:0005525

GO:0005634

GO:0005737

GO:0005765

GO:0005794

GO:0005834

GO:0005886

GO:0006469

GO:0007165

GO:0007186

GO:0007189

GO:0007200

GO:0007206

GO:0007208

GO:0007213

GO:0007215

GO:0007218

GO:0007596

GO:0007603

GO:0009649

GO:0010543

GO:0016020

GO:0016787

GO:0019001

GO:0030234

GO:0031683

GO:0031965

GO:0034695

GO:0043226

GO:0045202

GO:0046872

GO:0050821

GO:0060158

GO:0060828

GO:0070062

GO:0098772

HMNXSV003051830

Hs.296261.0.S3_3p_at

Hs.5437.3.A1_3p_at

Hs.5437.3.A2_3p_at

Hs.5437.3.A3_3p_at

ILMN_1659923

PH_hs_0033992

TC09001228.hg

U40038_at

U43083_at

g1181670_3p_a_at

g1181670_3p_x_at

p26496

Participates

as a member of

as a candidate of

G(q) alpha 11,14,15,Q [plasma membrane] (Homo sapiens)

Inferred To

Homologues of GNA11 [plasma membrane] (Dictyostelium discoideum)

Homologues of GNA11 [plasma membrane] (Drosophila melanogaster)

GNA11 [plasma membrane] (Caenorhabditis elegans)

GNA11 [plasma membrane] (Dictyostelium discoideum)

GNA11 [plasma membrane] (Drosophila melanogaster)

GNA11 [plasma membrane] (Saccharomyces cerevisiae)

GNA11 [plasma membrane] (Schizosaccharomyces pombe)

GNAQ [plasma membrane] (Bos taurus)

GNAQ [plasma membrane] (Canis familiaris)

GNAQ [plasma membrane] (Gallus gallus)

GNAQ [plasma membrane] (Mus musculus)

GNAQ [plasma membrane] (Rattus norvegicus)

GNAQ [plasma membrane] (Sus scrofa)

GNAQ [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_002063.2

Guide to Pharmacology - Targets

2914

ENSEMBL

ENST00000286548, ENSP00000286548, ENSG00000156052

OpenTargets

ENSG00000156052

GeneCards

GNAQ

HPA

ENSG00000156052-GNAQ

PRO

P50148

Pharos - Targets

P50148

Orphanet

GNAQ

HMDB Protein

HMDBP02022

PDB

7W3Z, 7XOW, 8JPB, 8IYS, 7F8W, 8G59, 8JPE, 8JPC, 8IA7, 7F6G, 6VU5, 8SZG, 7EZM, 7F6H, 7F6I, 8J9N, 8UQN, 7W40, 8ZJD, 8UQO

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.563	4
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.524	2

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