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MED8 [nucleoplasm]
Stable Identifier
R-HSA-556784
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Mediator of RNA polymerase II transcription subunit 8, MED8_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED8 [nucleoplasm] (Homo sapiens)
Expression of Adiponectin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED8 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED8 [nucleoplasm] (Homo sapiens)
Expression of CEBPA (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED8 [nucleoplasm] (Homo sapiens)
Expression of FABP4 (aP2) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED8 [nucleoplasm] (Homo sapiens)
Expression of Leptin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED8 [nucleoplasm] (Homo sapiens)
Expression of Lipoprotein lipase (LPL) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED8 [nucleoplasm] (Homo sapiens)
Expression of Perilipin (PLIN) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED8 [nucleoplasm] (Homo sapiens)
Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED8 [nucleoplasm] (Homo sapiens)
PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED8 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED8 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Formation of ARC coactivator complex (Homo sapiens)
ARC coactivator complex [nucleoplasm] (Homo sapiens)
MED8 [nucleoplasm] (Homo sapiens)
MED8 [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED8 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED8 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96G25 MED8
Gene Names
MED8
Chain
chain:1-268
Reference Genes
BioGPS Gene:112950 MED8
COSMIC (genes):MED8 MED8
CTD Gene:112950 MED8
dbSNP Gene:112950 MED8
ENSEMBL:ENSG00000159479 MED8
HGNC:19971 MED8
KEGG Gene (Homo sapiens):112950 MED8
Monarch:112950 MED8
NCBI Gene:112950 MED8
OMIM:607956 MED8
UCSC:Q96G25 MED8
Reference Transcript
RefSeq:NM_001001653.2 MED8
RefSeq:NM_052877.4 MED8
RefSeq:NM_201542.4 MED8
Other Identifiers
0000070458
0002900162
112950
11720990_a_at
11742968_a_at
16686140
213126_at
213127_s_at
213696_s_at
2409343
2409345
2409346
2409347
2409348
2409349
2409350
2409351
2409355
2409359
2409360
2409361
2409363
2409364
2409366
2409367
33432_at
7915516
A_23_P46170
A_24_P233915
GE83674
GO:0000978
GO:0003674
GO:0003677
GO:0003712
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0006357
GO:0006367
GO:0006464
GO:0008150
GO:0009058
GO:0016567
GO:0016592
GO:0032991
GO:0034641
GO:0043226
GO:0070847
Hs.301756.0.A1_3p_at
Hs.301756.2.S1_3p_a_at
ILMN_1659537
ILMN_1736847
ILMN_2339705
PH_hs_0015562
TC01002584.hg
Participant Of
hasComponent
ARC coactivator complex [nucleoplasm]
Mediator Complex (consensus) [nucleoplasm]
input
Formation of ARC coactivator complex
Inferred To
Mediator of RNA polymerase II transcription subunit 8 [nucleoplasm] (Mus musculus)
med8 [nucleoplasm] (Danio rerio)
med8 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_001001653.1
,
NP_963836.2
,
NP_443109.2
OpenTargets
ENSG00000159479
HPA
ENSG00000159479-MED8
GeneCards
Q96G25
Ensembl
ENSG00000159479
,
ENST00000372455
,
ENSP00000361533
,
ENST00000290663
,
ENSP00000290663
,
ENSP00000361535
,
ENST00000372457
PRO
Q96G25
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BTT4 MED10
1
MED10 [nucleoplasm]
(R-HSA-212410)
0.867
9
UniProt:P49336 CDK8
1
CDK8 [nucleoplasm]
(R-HSA-212440)
0.69
6
UniProt:Q9NX70 MED29
1
MED29 [nucleoplasm]
(R-HSA-556821)
0.643
3
UniProt:A0JLT2 MED19
1
MED19 [nucleoplasm]
(R-HSA-556819)
0.643
4
UniProt:Q9BWU1 CDK19
1
CDK19 [nucleoplasm]
(R-HSA-556782)
0.564
2
UniProt:Q15370 ELOB
2
TCEB2 [nucleoplasm]
(R-HSA-112423)
ELOB [cytosol]
(R-HSA-180551)
0.548
5
UniProt:Q15369 ELOC
2
TCEB1 [nucleoplasm]
(R-HSA-112422)
ELOC [cytosol]
(R-HSA-180535)
0.548
3
UniProt:P68336 VP16
0.527
2
UniProt:Q9NWA0 MED9
1
MED9 [nucleoplasm]
(R-HSA-556804)
0.527
3
UniProt:O95402 MED26
1
MED26 [nucleoplasm]
(R-HSA-556783)
0.527
3
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