Reactome | MED8 [nucleoplasm]

MED8 [nucleoplasm]

Stable Identifier

R-HSA-556784

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mediator of RNA polymerase II transcription subunit 8, MED8_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96G25 MED8

Gene Names

MED8

Chain

chain:1-268

Reference Genes

BioGPS Gene:112950 MED8

COSMIC (genes):MED8 MED8

CTD Gene:112950 MED8

dbSNP Gene:112950 MED8

ENSEMBL:ENSG00000159479 MED8

HGNC:19971 MED8

KEGG Gene (Homo sapiens):112950 MED8

Monarch:112950 MED8

NCBI Gene:112950 MED8

OMIM:607956 MED8

UCSC:Q96G25 MED8

Reference Transcript

Other Identifiers

0000070458

0002900162

112950

11720990_a_at

11742968_a_at

16686140

213126_at

213127_s_at

213696_s_at

2409343

2409345

2409346

2409347

2409348

2409349

2409350

2409351

2409355

2409359

2409360

2409361

2409363

2409364

2409366

2409367

33432_at

7915516

A_23_P46170

A_24_P233915

GE83674

GO:0000978

GO:0003674

GO:0003677

GO:0003712

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006357

GO:0006367

GO:0006464

GO:0008150

GO:0009058

GO:0016567

GO:0016592

GO:0032991

GO:0034641

GO:0043226

GO:0070847

Hs.301756.0.A1_3p_at

Hs.301756.2.S1_3p_a_at

ILMN_1659537

ILMN_1736847

ILMN_2339705

PH_hs_0015562

TC01002584.hg

Participant Of

hasComponent

input

Formation of ARC coactivator complex

Inferred To

Mediator of RNA polymerase II transcription subunit 8 [nucleoplasm] (Mus musculus)

med8 [nucleoplasm] (Danio rerio)

med8 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_963836.2, NP_001001653.1, NP_443109.2

OpenTargets

ENSG00000159479

HPA

ENSG00000159479-MED8

GeneCards

Q96G25

Ensembl

ENSP00000290663, ENST00000372457, ENST00000290663, ENST00000372455, ENSG00000159479, ENSP00000361535, ENSP00000361533

PRO

Q96G25

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.867	9
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.69	6
UniProt:Q9NX70 MED29	1	MED29 [nucleoplasm] (R-HSA-556821)	0.643	3
UniProt:A0JLT2 MED19	1	MED19 [nucleoplasm] (R-HSA-556819)	0.643	4
UniProt:Q9BWU1 CDK19	1	CDK19 [nucleoplasm] (R-HSA-556782)	0.564	2
UniProt:Q15369 ELOC	2	ELOC [cytosol] (R-HSA-180535) TCEB1 [nucleoplasm] (R-HSA-112422)	0.548	3
UniProt:Q15370 ELOB	2	ELOB [cytosol] (R-HSA-180551) TCEB2 [nucleoplasm] (R-HSA-112423)	0.548	5
UniProt:P68336 VP16			0.527	2
UniProt:Q9NWA0 MED9	1	MED9 [nucleoplasm] (R-HSA-556804)	0.527	3
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.527	3