Reactome | MED15 [nucleoplasm]

MED15 [nucleoplasm]

Stable Identifier

R-HSA-556827

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mediator of RNA polymerase II transcription subunit 15, MED15_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O95402 MED26

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External Reference Information

External Reference

UniProt:Q96RN5 MED15

Gene Names

MED15, ARC105, CTG7A, PCQAP, TIG1, TNRC7

Chain

chain:1-788

Reference Genes

BioGPS Gene:51586 MED15

COSMIC (genes):MED15 MED15

CTD Gene:51586 MED15

dbSNP Gene:51586 MED15

ENSEMBL:ENSG00000099917 MED15

HGNC:14248 MED15

KEGG Gene (Homo sapiens):51586 MED15

Monarch:51586 MED15

NCBI Gene:51586 MED15

OMIM:607372 MED15

UCSC:Q96RN5 MED15

Reference Transcript

Other Identifiers

0005360735

11716181_x_at

11747863_a_at

11748144_a_at

11750393_a_at

11750394_x_at

11752390_x_at

11755441_x_at

222175_s_at

2576392

3937594

3937595

3937601

3937605

3937608

3937610

3937611

3937614

3937615

3937618

3937619

3937620

3937621

3937626

3937627

3937633

3937635

3937637

3937638

3937640

3937642

3937643

3937644

3937646

3937648

3937651

3937652

51586

55103_at

8071392

A_24_P207727

GE55329

GO:0003674

GO:0003712

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0006355

GO:0006357

GO:0006367

GO:0008150

GO:0009058

GO:0016020

GO:0016592

GO:0019827

GO:0032991

GO:0034641

GO:0043226

Hs.8657.1.S1_3p_a_at

ILMN_1668748

ILMN_1706200

PH_hs_0040697

TC22000978.hg

Participant Of

hasComponent

input

Formation of ARC coactivator complex

Inferred To

med15 [nucleoplasm] (Danio rerio)

papss2 [nucleoplasm] (Xenopus tropicalis)

Med15 [nucleoplasm] (Mus musculus)

MED15 [nucleoplasm] (Canis familiaris)

Cross References

RefSeq

NP_001280165.1, NP_001003891.1, NP_056973.2, NP_001280164.1

OpenTargets

ENSG00000099917

HPA

ENSG00000099917-MED15

GeneCards

Q96RN5

Ensembl

ENSP00000292733, ENSG00000099917, ENST00000382974, ENST00000263205, ENSP00000372434, ENST00000292733, ENSP00000263205

PRO

Q96RN5

PDB

2GUT

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.81	12
UniProt:P36956-1 SREBF1	5	SREBF1-1 [Golgi membrane] (R-HSA-1655753) SREBF1-1 [endoplasmic reticulum membrane] (R-HSA-1655757) SREBF1-1(1-530) [Golgi membrane] (R-HSA-1655718) SREBF1-1(1-490) [cytosol] (R-HSA-1655764) SREBF1-1(1-490) [nucleoplasm] (R-HSA-1655755)	0.747	7
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.621	3
UniProt:Q9BWU1 CDK19	1	CDK19 [nucleoplasm] (R-HSA-556782)	0.564	2
UniProt:A0JLT2 MED19	1	MED19 [nucleoplasm] (R-HSA-556819)	0.527	2
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.527	3
UniProt:P61088 UBE2N	5	Ub-C87-UBE2N [cytosol] (R-HSA-8864210) Ub-C87-UBE2N [nucleoplasm] (R-HSA-8943013) K63polyUb-C87-UBE2N [nucleoplasm] (R-HSA-6790511) UBE2N [nucleoplasm] (R-HSA-5682541) UBE2N [cytosol] (R-HSA-206072)	0.508	2
UniProt:Q12772 SREBF2	5	SREBF2(1-1141) [Golgi membrane] (R-HSA-1655747) SREBF2(1-1141) [endoplasmic reticulum membrane] (R-HSA-1655733) SREBF2(1-522) [Golgi membrane] (R-HSA-1655752) SREBF2(1-484) [cytosol] (R-HSA-1655723) SREBF2(1-484) [nucleoplasm] (R-HSA-1655745)	0.499	2
UniProt:P36956-3 SREBF1	5	SREBF1-3 [endoplasmic reticulum membrane] (R-HSA-1655761) SREBF1-3 [nucleoplasm] (R-HSA-1655716) SREBF1-3 [Golgi membrane] (R-HSA-1655760) SREBF1-3 [Golgi membrane] (R-HSA-1655724) SREBF1-3 [cytosol] (R-HSA-1655721)	0.499	2
UniProt:Q96F44 TRIM11	1	TRIM11 [cytosol] (R-HSA-976033)	0.463	5

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