Phase 0 - rapid depolarisation

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R-HSA-5576892
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Pathway
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Homo sapiens
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Phase 0 is the rapid depolarisation phase in which electrical stimulation of a cell initiates events involving the influx and efflux of ions resulting in the production of a cell's action potential. The cell's excitation opens the closed, fast Na+ channel proteins, causing a large influx of Na+ creating a Na+ current (INa+). This causes depolarisation of the cell then voltage-dependent L-type calcium channels (LTCCs) transport Ca2+ into excitable cells. The slope of phase 0 represents the maximum rate of potential change and differs in contractile and pacemaker cells. The potential in this phase changes from around -90mV to around +50mV (Park & Fishman 2011, Grant 2009).

Literature References
PubMed ID Title Journal Year
19808464 Cardiac ion channels

Grant, AO

Circ Arrhythm Electrophysiol 2009
21357845 The cardiac conduction system

Park, DS, Fishman, GI

Circulation 2011
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