Phase 1 - inactivation of fast Na+ channels

Stable Identifier
R-HSA-5576894
Type
Pathway
Species
Homo sapiens
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Phase 1 of the cardiac action potential is the inactivation of the fast Na+ channels. The transient net outward current causing the small downward deflection (the "notch" of the action potetial) is due to the movement of K+ and Cl- ions. In pacemaker cells, this phase is due to rapid K+ efflux and closure of L-type Ca2+ channels (Park & Fishman 2011, Grant 2009).

Literature References
PubMed ID Title Journal Year
19808464 Cardiac ion channels

Grant, AO

Circ Arrhythm Electrophysiol 2009
21357845 The cardiac conduction system

Park, DS, Fishman, GI

Circulation 2011
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Orthologous Events
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