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EIF2C2 [nucleoplasm]
Stable Identifier
R-HSA-5578701
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Argonaute-2, AGO2
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Gene Silencing by RNA (Homo sapiens)
Transcriptional regulation by small RNAs (Homo sapiens)
AGO1,2:small RNA complexes interact with chromatin (Homo sapiens)
AGO1,2:miRNA [nucleoplasm] (Homo sapiens)
AGO2:miRNA [nucleoplasm] (Homo sapiens)
EIF2C2 [nucleoplasm] (Homo sapiens)
AGO1,2:miRNA:chromatin:RNA pol II [nucleoplasm] (Homo sapiens)
AGO1,2:miRNA [nucleoplasm] (Homo sapiens)
AGO2:miRNA [nucleoplasm] (Homo sapiens)
EIF2C2 [nucleoplasm] (Homo sapiens)
Importin-8 imports AGO2:miRNA into the nucleus (Homo sapiens)
AGO2:miRNA [nucleoplasm] (Homo sapiens)
EIF2C2 [nucleoplasm] (Homo sapiens)
TNRC6A:AGO2:miRNA is transported into the nucleus (Homo sapiens)
TNRC6A:AGO2:miRNA [nucleoplasm] (Homo sapiens)
AGO2:miRNA [nucleoplasm] (Homo sapiens)
EIF2C2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UKV8 AGO2
Gene Names
AGO2, EIF2C2
Chain
chain:1-859
Reference Genes
BioGPS Gene:27161 AGO2
COSMIC (genes):AGO2 AGO2
CTD Gene:27161 AGO2
dbSNP Gene:27161 AGO2
ENSEMBL:ENSG00000123908.12 AGO2
HGNC:3263 AGO2
KEGG Gene (Homo sapiens):27161 AGO2
Monarch:27161 AGO2
NCBI Gene:27161 AGO2
OMIM:606229 AGO2
UCSC:Q9UKV8 AGO2
Reference Transcript
RefSeq:NM_012154.4 AGO2
RefSeq:NM_001164623.2 AGO2
Other Identifiers
0004150100
11754098_a_at
1561042_PM_at
1561042_at
17081706
17081708
213310_PM_at
213310_at
225569_PM_at
225569_at
225827_PM_at
225827_at
243304_PM_at
243304_at
27161
3156186
3156188
3156190
3156192
3156194
3156195
3156196
3156197
3156198
3156199
3156200
3156201
3156202
3156203
3156204
3156205
3156206
3156207
3156208
3156209
3156210
3156214
3156215
3156219
3156220
3156221
3156224
3156225
3156227
3156228
3156234
3156235
3156238
3156239
3156241
3156243
3156244
3156247
3156249
3156263
3156264
3156274
3156275
3156292
38505_at
48698_at
56226_at
58633_s_at
65694_at
8153201
82897_at
A_19_P00317929
A_23_P112159
A_33_P3651911
GE56259
GE87268
GO:0000340
GO:0000932
GO:0000993
GO:0001046
GO:0003676
GO:0003677
GO:0003723
GO:0003725
GO:0003727
GO:0003729
GO:0003743
GO:0004518
GO:0004519
GO:0004521
GO:0005515
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005844
GO:0005845
GO:0006351
GO:0006355
GO:0006412
GO:0006413
GO:0006417
GO:0008022
GO:0009791
GO:0010501
GO:0010586
GO:0010628
GO:0016020
GO:0016071
GO:0016442
GO:0016787
GO:0016891
GO:0022414
GO:0030422
GO:0030425
GO:0031047
GO:0031054
GO:0032991
GO:0035194
GO:0035196
GO:0035197
GO:0035198
GO:0035278
GO:0035279
GO:0036464
GO:0042985
GO:0043226
GO:0045182
GO:0045766
GO:0045944
GO:0045947
GO:0046872
GO:0048856
GO:0048870
GO:0060213
GO:0065003
GO:0070062
GO:0070551
GO:0070578
GO:0070922
GO:0090305
GO:0090502
GO:0090624
GO:0090625
GO:0098808
GO:0140098
GO:1900153
GO:1901135
GO:1901165
GO:1990904
HMNXSV003039023
HMNXSV003055196
Hs.146082.0.A1_3p_at
Hs.193053.0.A1_3p_at
Hs.193053.1.A1_3p_at
Hs.324504.1.A1_3p_at
Hs2.287797.8.S1_3p_at
ILMN_1695719
PH_hs_0026253
PH_hs_0040296
TC08001683.hg
TC08001684.hg
TC08002551.hg
p15964
p26467
Participates
as a component of
AGO2:miRNA [nucleoplasm] (Homo sapiens)
Other forms of this molecule
AGO2 [cytosol]
Inferred To
EIF2C2 [nucleoplasm]
(Bos taurus)
EIF2C2 [nucleoplasm]
(Canis familiaris)
EIF2C2 [nucleoplasm]
(Danio rerio)
EIF2C2 [nucleoplasm]
(Gallus gallus)
EIF2C2 [nucleoplasm]
(Mus musculus)
EIF2C2 [nucleoplasm]
(Rattus norvegicus)
EIF2C2 [nucleoplasm]
(Sus scrofa)
EIF2C2 [nucleoplasm]
(Xenopus tropicalis)
AGO1 [nucleoplasm]
(Drosophila melanogaster)
ago1 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001158095.1
,
NP_036286.2
OpenTargets
ENSG00000123908
HPA
ENSG00000123908-AGO2
GeneCards
Q9UKV8
Ensembl
ENST00000220592
,
ENSG00000123908
,
ENSP00000220592
,
ENSP00000430176
,
ENST00000519980
PRO
Q9UKV8
Pharos - Targets
Q9UKV8
Orphanet
24337
PDB
4W5R
,
3LUH
,
4OLB
,
5JS2
,
6MFR
,
3QX9
,
4F3T
,
6NIT
,
4Z4D
,
4W5T
,
4Z4F
,
5T7B
,
5WEA
,
4Z4E
,
3LUJ
,
6CBD
,
7C6B
,
7D7U
,
7KI3
,
4Z4G
,
3LUC
,
4W5O
,
6N4O
,
4W5N
,
3LUK
,
5KI6
,
3LUD
,
5JS1
,
4Z4C
,
6RA4
,
6MDZ
,
3LUG
,
4Z4I
,
6MFN
,
4W5Q
,
4OLA
,
4Z4H
,
3QX8
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NDV7 TNRC6A
2
TNRC6A [cytosol]
(R-HSA-427769)
TNRC6A [nucleoplasm]
(R-HSA-5578976)
0.953
22
UniProt:Q9UPY3 DICER1
1
DICER1 [cytosol]
(R-HSA-203820)
0.942
20
UniProt:O15397 IPO8
2
IPO8 [nucleoplasm]
(R-HSA-5578747)
IPO8 [cytosol]
(R-HSA-5578740)
0.688
4
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.679
11
UniProt:P11940 PABPC1
1
PABPC1 [cytosol]
(R-HSA-156803)
0.643
6
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.564
3
UniProt:Q08211 DHX9
2
DHX9 [cytosol]
(R-HSA-847700)
DHX9 [nucleoplasm]
(R-HSA-53517)
0.527
3
UniProt:P67809 YBX1
3
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.527
3
UniProt:Q13541 EIF4EBP1
2
EIF4EBP1 [cytosol]
(R-HSA-72580)
p-T37,T46-EIF4EBP1 [cytosol]
(R-HSA-165685)
0.524
2
UniProt:Q9UHD2 TBK1
4
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
p-TBK1 [cytosol]
(R-HSA-9008705)
p-S172-TBK1 [cytosol]
(R-HSA-168379)
TBK1 [cytosol]
(R-HSA-166267)
0.499
2
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.499
2
UniProt:Q15185 PTGES3
2
PTGES3 [nucleoplasm]
(R-HSA-5082403)
PTGES3 [cytosol]
(R-HSA-265269)
0.499
3
UniProt:Q02790 FKBP4
3
FKBP4 [nucleoplasm]
(R-HSA-8939162)
FKBP4 [nucleoplasm]
(R-HSA-5324621)
FKBP4 [cytosol]
(R-HSA-5618108)
0.499
2
UniProt:P04156 PRNP
2
PRNP [cytosol]
(R-HSA-9617597)
PRNP [plasma membrane]
(R-HSA-375060)
0.499
4
UniProt:Q96C10 DHX58
1
DHX58 [cytosol]
(R-HSA-913540)
0.499
2
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.499
3
UniProt:O14980 XPO1
2
XPO1 [nucleoplasm]
(R-HSA-165529)
XPO1 [cytosol]
(R-HSA-165539)
0.462
2
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.462
2
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