Reactome | IPO8 [cytosol]

IPO8 [cytosol]

Stable Identifier

R-HSA-5578740

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Importin-8, IPO8_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O15397 IPO8

Gene Names

IPO8, RANBP8

Chain

chain:1-1037

Reference Genes

BioGPS Gene:10526 IPO8

COSMIC (genes):IPO8 IPO8

CTD Gene:10526 IPO8

dbSNP Gene:10526 IPO8

ENSEMBL:ENSG00000133704 IPO8

HGNC:9853 IPO8

Monarch:10526 IPO8

NCBI Gene:10526 IPO8

OMIM:605600 IPO8

UCSC:O15397 IPO8

Reference Transcript

Other Identifiers

10526

11724868_a_at

11724869_x_at

11724870_a_at

11746544_a_at

16762798

205701_PM_at

205701_at

225528_PM_at

225528_at

3449320

3449321

3449322

3449325

3449326

3449330

3449331

3449332

3449333

3449334

3449335

3449336

3449338

3449339

3449340

3449341

3449342

3449343

3449344

3449346

3449347

3449348

3449349

3449350

3449351

3449352

3449353

3449354

3449355

3449356

3449357

3449358

3449360

3449361

3449363

3449366

3449367

35123_at

4053690

55735_at

7962085

A_23_P98923

A_33_P3369286

GE59412

GO:0005515

GO:0005634

GO:0005635

GO:0005654

GO:0005737

GO:0005829

GO:0006606

GO:0006886

GO:0006913

GO:0007165

GO:0015031

GO:0031267

GO:0043226

HMNXSV003017531

Hs.9961.0.A1_3p_at

ILMN_1753164

PH_hs_0032639

TC12001353.hg

TC12001354.hg

g5453999_3p_at

Participates

as an input of

Importin-8 binds AGO2:miRNA (Homo sapiens)

as a component of

IPO8:AGO2:miRNA [cytosol] (Homo sapiens)

Other forms of this molecule

IPO8 [nucleoplasm]

Inferred To

Ipo8 [cytosol] (Mus musculus)

Ipo8 [cytosol] (Rattus norvegicus)

msk [cytosol] (Drosophila melanogaster)

NMD5 [cytosol] (Saccharomyces cerevisiae)

IPO8 [cytosol] (Bos taurus)

IPO8 [cytosol] (Canis familiaris)

IPO8 [cytosol] (Dictyostelium discoideum)

IPO8 [cytosol] (Gallus gallus)

IPO8 [cytosol] (Schizosaccharomyces pombe)

IPO8 [cytosol] (Sus scrofa)

ipo8 [cytosol] (Danio rerio)

Cross References

OpenTargets

ENSG00000133704

ENSEMBL

ENSP00000256079, ENST00000256079, ENSP00000444520, ENST00000544829

HPA

ENSG00000133704-IPO8

PRO

O15397

Pharos - Targets

O15397

GlyGen

O15397

HMDB Protein

HMDBP08468

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NQX6 ZNF331	1	ZNF331 [nucleoplasm] (R-HSA-1247549)	0.708	5
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) AGO2 [nucleoplasm] (R-HSA-5578701)	0.688	4
UniProt:Q9BUG6 ZSA5A			0.643	4
UniProt:Q9Y275 TNFSF13B	1	sBAFF [extracellular region] (R-HSA-5676541)	0.643	3
UniProt:Q9BWE0 REPI1			0.643	3
UniProt:Q13263 TRIM28	3	TRIM28 [nucleoplasm] (R-HSA-974998) SUMO2-K554,K575,K676,K750,K779,K804-TRIM28 [nucleoplasm] (R-HSA-9842867) SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm] (R-HSA-3782600)	0.643	4
UniProt:Q9H9G7 AGO3	1	EIF2C3 [cytosol] (R-HSA-210615)	0.637	5
UniProt:Q9HCK5 AGO4	1	EIF2C4 [cytosol] (R-HSA-210612)	0.576	3
UniProt:Q6NX45 ZNF774	1	ZNF774 [nucleoplasm] (R-HSA-3110232)	0.556	3
UniProt:Q6ZN57 ZFP2	1	ZFP2 [nucleoplasm] (R-HSA-975018)	0.556	3
UniProt:O43296 ZNF264	1	ZNF264 [nucleoplasm] (R-HSA-1027386)	0.556	3
UniProt:P19544-6 WT1			0.556	3
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.544	2
UniProt:Q15797 SMAD1	4	p-S463,S465-SMAD1 [nucleoplasm] (R-HSA-201483) p-S463,S465-SMAD1 [cytosol] (R-HSA-201464) SMAD1 [cytosol] (R-HSA-201468) Ub-SMAD1 [cytosol] (R-HSA-6782768)	0.544	2
UniProt:P17097 ZNF7			0.527	2
UniProt:P43115 PTGER3	1	PTGER3 [plasma membrane] (R-HSA-391828)	0.527	2
UniProt:Q6P2D0 ZFP1	1	ZFP1 [nucleoplasm] (R-HSA-974997)	0.527	2
UniProt:Q9UEG4 ZN629			0.527	2
UniProt:Q96DT7 ZBT10			0.527	2
UniProt:Q5SSJ5 HP1B3			0.527	2
UniProt:Q16587 ZNF74	1	ZNF74 [nucleoplasm] (R-HSA-2586601)	0.527	2
UniProt:Q8N7X8 SIGL1			0.527	2
UniProt:Q96H86 ZNF764	1	ZNF764 [nucleoplasm] (R-HSA-3343766)	0.527	2
UniProt:Q86Y25 ZNF354C	1	ZNF354C [nucleoplasm] (R-HSA-1247525)	0.527	2
UniProt:Q14592 ZNF460	1	ZNF460 [nucleoplasm] (R-HSA-1027424)	0.527	3
UniProt:Q96SR6 ZNF382	1	ZNF382 [nucleoplasm] (R-HSA-1247533)	0.527	2
UniProt:Q9UL18 AGO1	2	EIF2C1 [nucleoplasm] (R-HSA-5578686) EIF2C1 [cytosol] (R-HSA-210616)	0.524	2
UniProt:P27105 STOM	4	STOM [azurophil granule membrane] (R-HSA-6800997) STOM [plasma membrane] (R-HSA-6806258) STOM [specific granule membrane] (R-HSA-6799569) STOM [tertiary granule membrane] (R-HSA-6800960)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8

Cite Us!