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IPO8 [cytosol]
Stable Identifier
R-HSA-5578740
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Importin-8, IPO8_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q6NX45
Expand all
Gene expression (Transcription) (Homo sapiens)
Gene Silencing by RNA (Homo sapiens)
Transcriptional regulation by small RNAs (Homo sapiens)
Importin-8 binds AGO2:miRNA (Homo sapiens)
IPO8 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15397 IPO8
Gene Names
IPO8, RANBP8
Chain
chain:1-1037
Reference Genes
BioGPS Gene:10526 IPO8
COSMIC (genes):IPO8 IPO8
CTD Gene:10526 IPO8
dbSNP Gene:10526 IPO8
ENSEMBL:ENSG00000133704 IPO8
ENSEMBL_homo_sapiens_GENE:ENSG00000133704.10 IPO8
HGNC:9853 IPO8
KEGG Gene (Homo sapiens):10526 IPO8
Monarch:10526 IPO8
NCBI Gene:10526 IPO8
OMIM:605600 IPO8
UCSC:O15397 IPO8
Reference Transcript
RefSeq:NM_001190995.1 IPO8
RefSeq:NM_006390.3 IPO8
Other Identifiers
10526
11724868_a_at
11724869_x_at
11724870_a_at
11746544_a_at
16762798
205701_PM_at
205701_at
225528_PM_at
225528_at
3449320
3449321
3449322
3449326
3449330
3449331
3449332
3449333
3449334
3449335
3449336
3449338
3449339
3449340
3449341
3449342
3449343
3449344
3449346
3449347
3449348
3449349
3449350
3449351
3449352
3449353
3449355
3449356
3449358
3449360
3449361
3449366
3449367
35123_at
4053690
55735_at
7962085
A_23_P98923
A_33_P3369286
GE59412
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005737
GO:0005829
GO:0006606
GO:0006886
GO:0006913
GO:0007165
GO:0015031
GO:0023052
GO:0031267
GO:0043226
HMNXSV003017531
Hs.9961.0.A1_3p_at
ILMN_1753164
PH_hs_0032639
TC12001353.hg
g5453999_3p_at
Participates
as an input of
Importin-8 binds AGO2:miRNA (Homo sapiens)
as a component of
IPO8:AGO2:miRNA [cytosol] (Homo sapiens)
Other forms of this molecule
IPO8 [nucleoplasm]
Inferred To
Ipo8 [cytosol]
(Mus musculus)
Ipo8 [cytosol]
(Rattus norvegicus)
msk [cytosol]
(Drosophila melanogaster)
NMD5 [cytosol]
(Saccharomyces cerevisiae)
IPO8 [cytosol]
(Bos taurus)
IPO8 [cytosol]
(Canis familiaris)
IPO8 [cytosol]
(Dictyostelium discoideum)
IPO8 [cytosol]
(Gallus gallus)
IPO8 [cytosol]
(Schizosaccharomyces pombe)
IPO8 [cytosol]
(Sus scrofa)
ipo8 [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_001177924.1
,
NP_006381.2
OpenTargets
ENSG00000133704
GeneCards
O15397
HPA
ENSG00000133704-IPO8
Ensembl
ENSP00000444520
,
ENST00000544829
,
ENSP00000256079
,
ENSG00000133704
,
ENST00000256079
PRO
O15397
Pharos - Targets
O15397
HMDB Protein
HMDBP08468
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UKV8 AGO2
2
AGO2 [nucleoplasm]
(R-HSA-5578701)
AGO2 [cytosol]
(R-HSA-209723)
0.688
4
UniProt:Q9H9G7 AGO3
1
EIF2C3 [cytosol]
(R-HSA-210615)
0.637
5
UniProt:Q9HCK5 AGO4
1
EIF2C4 [cytosol]
(R-HSA-210612)
0.576
3
UniProt:O43296 ZNF264
1
ZNF264 [nucleoplasm]
(R-HSA-1027386)
0.556
3
UniProt:Q6NX45 ZNF774
1
ZNF774 [nucleoplasm]
(R-HSA-3110232)
0.556
3
UniProt:P19544-6 WT1
0.556
3
UniProt:Q6ZN57 ZFP2
1
ZFP2 [nucleoplasm]
(R-HSA-975018)
0.556
3
UniProt:Q15797 SMAD1
4
Ub-SMAD1 [cytosol]
(R-HSA-6782768)
SMAD1 [cytosol]
(R-HSA-201468)
p-S463,S465-SMAD1 [cytosol]
(R-HSA-201464)
p-S463,S465-SMAD1 [nucleoplasm]
(R-HSA-201483)
0.544
2
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
0.544
2
UniProt:Q9BUG6 ZSA5A
0.527
2
UniProt:Q9Y275 TNFSF13B
1
sBAFF [extracellular region]
(R-HSA-5676541)
0.527
2
UniProt:P17097 ZNF7
0.527
2
UniProt:Q9BWE0 REPI1
0.527
2
UniProt:Q9NQX6 ZNF331
1
ZNF331 [nucleoplasm]
(R-HSA-1247549)
0.527
2
UniProt:Q86Y25 ZNF354C
1
ZNF354C [nucleoplasm]
(R-HSA-1247525)
0.527
2
UniProt:Q9UL18 AGO1
2
EIF2C1 [nucleoplasm]
(R-HSA-5578686)
EIF2C1 [cytosol]
(R-HSA-210616)
0.524
2
UniProt:P27105 STOM
4
STOM [tertiary granule membrane]
(R-HSA-6800960)
STOM [plasma membrane]
(R-HSA-6806258)
STOM [specific granule membrane]
(R-HSA-6799569)
STOM [azurophil granule membrane]
(R-HSA-6800997)
0.508
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
8
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