Reactome | CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)

CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)

Stable Identifier

R-HSA-5578783

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

Synonyms

CORIN(802-1042) hydrolyses natriuretic peptides A (NPPA) to form atrial natriuretic factor (ANF)

ReviewStatus

5/5

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CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)

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Atrial natriuretic factor (NPPA(124-151) aka ANF) is a cardiac hormone essential for the regulation of blood pressure and promoting natriuresis, diuresis and vasodilation. In cardiac myocytes, NPPA is synthesised as an inactive precursor, pro-NPPA, that is converted to the biologically-active form by cleavage. Atrial natriuretic peptide-converting enzyme (CORIN) is the serine-type endopeptidase involved in NPPA processing. It is itself cleaved into 5 chains, with CORIN(802-1042) being the activated protease fragment (Yan et al. 2000, Knappe et al. 2003, Liao et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17660514	Role of glycosylation in corin zymogen activation Liao, X, Wang, W, Chen, S, Wu, Q	J. Biol. Chem.	2007
10880574	Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme Yan, W, Wu, F, Morser, J, Wu, Q	Proc. Natl. Acad. Sci. U.S.A.	2000
14559895	Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin Knappe, S, Wu, F, Masikat, MR, Morser, J, Wu, Q	J. Biol. Chem.	2003