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NPPA(1-25) [extracellular region]
Stable Identifier
R-HSA-5578791
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
NPPA signal peptide
Locations in the PathwayBrowser
Expand all
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Physiological factors (Homo sapiens)
CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Homo sapiens)
NPPA(1-25) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01160 NPPA
Gene Names
NPPA, ANP, PND
Chain
signal peptide:1-25, chain:26-151, peptide:26-55, peptide:56-92, propeptide:93-103, peptide:104-123, peptide:119-151, peptide:120-151, peptide:121-145, peptide:124-151, peptide:127-151, peptide:127-150, peptide:128-151, peptide:128-150, peptide:128-148
Reference Genes
BioGPS Gene:4878 NPPA
COSMIC (genes):NPPA NPPA
CTD Gene:4878 NPPA
dbSNP Gene:4878 NPPA
ENSEMBL:ENSG00000175206 NPPA
ENSEMBL_homo_sapiens_GENE:ENSG00000175206.11 NPPA
HGNC:7939 NPPA
KEGG Gene (Homo sapiens):4878 NPPA
Monarch:4878 NPPA
NCBI Gene:4878 NPPA
OMIM:108780 NPPA
UCSC:P01160 NPPA
Reference Transcript
RefSeq:NM_006172.3 NPPA
Other Identifiers
11757468_a_at
16681799
209957_PM_s_at
209957_s_at
2396850
2396853
2396854
2396855
2396856
36663_at
4878
73106_s_at
7912515
A_23_P74059
GE80253
GO:0003008
GO:0003012
GO:0003013
GO:0003085
GO:0003161
GO:0003180
GO:0005102
GO:0005179
GO:0005184
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0006182
GO:0006457
GO:0007168
GO:0007218
GO:0007565
GO:0008217
GO:0010460
GO:0014898
GO:0019934
GO:0022414
GO:0023052
GO:0030312
GO:0031012
GO:0032991
GO:0035994
GO:0036211
GO:0036376
GO:0042311
GO:0042995
GO:0043204
GO:0043508
GO:0045776
GO:0048018
GO:0048856
GO:0051427
GO:0055085
GO:0055086
GO:0060372
GO:0060452
GO:0062023
GO:0071855
GO:0097746
GO:0098772
GO:1901135
GO:1901841
GO:1902261
GO:1902514
GO:1903766
HMNXSV003011416
ILMN_1750386
M54951_at
PH_hs_0004354
PH_hs_0031323
TC01002204.hg
g180181_3p_s_at
Participates
as an output of
CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Homo sapiens)
Other forms of this molecule
NPPA(124-151) [extracellular region]
NPPA(1-151) [extracellular region]
NPPA(56-123) [extracellular region]
NPPA(26-55) [extracellular region]
Inferred To
Nppa [extracellular region]
(Mus musculus)
Nppa [extracellular region]
(Rattus norvegicus)
NPPA [extracellular region]
(Bos taurus)
NPPA [extracellular region]
(Canis familiaris)
NPPA [extracellular region]
(Sus scrofa)
nppa [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_006163.1
OpenTargets
ENSG00000175206
GeneCards
P01160
ZINC - Substances
ANF_HUMAN
HPA
ENSG00000175206-NPPA
Ensembl
ENST00000376480
,
ENSG00000175206
,
ENSP00000365663
ZINC target
P01160
PRO
P01160
Pharos - Targets
P01160
ZINC - Predictions - Purchasable
ANF_HUMAN
Orphanet
18488
PDB
7BRH
,
7BRK
,
1ANP
,
1YK0
,
7BRJ
,
3N57
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P43365 MAGAC
0.718
6
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
UniProt:O75031 HSF2B
0.556
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:O75342 ALOX12B
1
ALOX12B [cytosol]
(R-HSA-2142832)
0.527
2
UniProt:O60911 CTSV
4
CTSL2 [lysosomal lumen]
(R-HSA-1181232)
CTSL2 [early endosome lumen]
(R-HSA-4127471)
CTSL2 [extracellular region]
(R-HSA-2228669)
CTSL2 [endolysosome lumen]
(R-HSA-4127477)
0.527
2
UniProt:A8K2U0 A2ML1
0.527
2
UniProt:P07476 IVL
2
IVL [cornified envelope]
(R-HSA-8847720)
IVL [cytosol]
(R-HSA-6810837)
0.527
2
UniProt:Q9UI42 CBPA4
0.527
2
UniProt:Q8NEX9 SDR9C7
1
SDR9C7 [endoplasmic reticulum membrane]
(R-HSA-4084690)
0.527
2
UniProt:P14923 JUP
6
JUP [cytosol]
(R-HSA-201598)
JUP [cornified envelope]
(R-HSA-8847739)
JUP [specific granule lumen]
(R-HSA-6799534)
JUP [extracellular region]
(R-HSA-6806309)
JUP [ficolin-1-rich granule lumen]
(R-HSA-6801028)
JUP [plasma membrane]
(R-HSA-437260)
0.527
2
UniProt:P48594 SPB4
0.527
2
UniProt:Q6GTS8 PM20D1
1
PM20D1 [extracellular region]
(R-HSA-9673052)
0.527
2
UniProt:Q10713 PMPCA
1
PMPCA [mitochondrial matrix]
(R-HSA-1299450)
0.527
2
UniProt:Q5TEU4 NDUFAF5
1
NDUFAF5 [mitochondrial inner membrane]
(R-HSA-5689127)
0.527
2
UniProt:Q9NRG4 SMYD2
1
SMYD2 [nucleoplasm]
(R-HSA-3222233)
0.527
2
UniProt:P22735 TGM1
3
TGM1 [cytosol]
(R-HSA-6813756)
TGM1 [cornified envelope]
(R-HSA-8847706)
TGM1 [plasma membrane]
(R-HSA-6813757)
0.527
2
UniProt:P29508 SERPINB3
2
SERPINB3 [extracellular region]
(R-HSA-6806189)
SERPINB3 [azurophil granule lumen]
(R-HSA-6799340)
0.527
2
UniProt:P53582 METAP1
1
METAP1 [cytosol]
(R-HSA-2534097)
0.527
2
UniProt:Q15126 PMVK
1
PMVK [cytosol]
(R-HSA-191348)
0.527
2
UniProt:O75439 PMPCB
1
PMPCB [mitochondrial matrix]
(R-HSA-1299434)
0.527
2
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