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p-S16-PLN [sarcoplasmic reticulum membrane]
Stable Identifier
R-HSA-5578813
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
sarcoplasmic reticulum membrane
Synonyms
Cardiac phospholamban, PPLA_HUMAN
Locations in the PathwayBrowser
Expand all
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Homo sapiens)
p-S16-PLN pentamer [sarcoplasmic reticulum membrane] (Homo sapiens)
p-S16-PLN [sarcoplasmic reticulum membrane] (Homo sapiens)
DMPK phosphorylates PLN (Homo sapiens)
p-S16-PLN pentamer [sarcoplasmic reticulum membrane] (Homo sapiens)
p-S16-PLN [sarcoplasmic reticulum membrane] (Homo sapiens)
PRKACA phosphorylates PLN (Homo sapiens)
p-S16-PLN pentamer [sarcoplasmic reticulum membrane] (Homo sapiens)
p-S16-PLN [sarcoplasmic reticulum membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Ion transport by P-type ATPases (Homo sapiens)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Homo sapiens)
p-S16-PLN pentamer [sarcoplasmic reticulum membrane] (Homo sapiens)
p-S16-PLN [sarcoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P26678 PLN
Gene Names
PLN, PLB
Chain
chain:1-52
Reference Genes
BioGPS Gene:5350 PLN
COSMIC (genes):PLN PLN
CTD Gene:5350 PLN
dbSNP Gene:5350 PLN
ENSEMBL:ENSG00000198523 PLN
HGNC:9080 PLN
KEGG:hsa:5350 PLN
Monarch:5350 PLN
NCBI Gene:5350 PLN
OMIM:172405 PLN
UCSC:P26678 PLN
Reference Transcript
RefSeq:NM_002667.4 PLN
Other Identifiers
11723644_a_at
11723645_at
11764124_s_at
17012100
204938_PM_s_at
204938_s_at
204939_PM_s_at
204939_s_at
204940_PM_at
204940_at
228202_PM_at
228202_at
2923271
2923273
2923274
2923275
2923276
2923277
2923278
2923279
2923280
2923281
2923283
2923285
2923287
38734_at
5350
8121729
87826_s_at
89608_r_at
A_14_P201133
A_23_P30614
A_24_P414803
A_32_P213418
GE470744
GE58027
GO:0001675
GO:0002026
GO:0003012
GO:0003013
GO:0004857
GO:0005515
GO:0005739
GO:0005783
GO:0005789
GO:0006874
GO:0007219
GO:0007283
GO:0008015
GO:0008016
GO:0008542
GO:0010459
GO:0010880
GO:0010881
GO:0016020
GO:0016529
GO:0022414
GO:0031966
GO:0032780
GO:0033017
GO:0042030
GO:0042802
GO:0042803
GO:0043086
GO:0043226
GO:0045475
GO:0045822
GO:0046716
GO:0048471
GO:0048738
GO:0048856
GO:0050802
GO:0050877
GO:0051117
GO:0051480
GO:0051924
GO:0051926
GO:0055119
GO:0086004
GO:0086023
GO:0086036
GO:0086092
GO:0090279
GO:0090281
GO:0090534
GO:0098772
GO:1901020
GO:1901077
GO:1901877
GO:1901894
GO:1901895
GO:1901897
GO:1902081
HMNXSV003027943
Hs.85050.1.A1_3p_at
ILMN_1730811
ILMN_2192245
M63603_at
PH_hs_0037401
TC06000935.hg
TC06003017.hg
g190018_3p_a_at
g4505886_3p_a_at
Participates
as a component of
p-S16-PLN pentamer [sarcoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
PLN [sarcoplasmic reticulum membrane]
Inferred To
phospho-pln [sarcoplasmic reticulum membrane]
(Xenopus tropicalis)
phospho-Pln [sarcoplasmic reticulum membrane]
(Mus musculus)
phospho-Pln [sarcoplasmic reticulum membrane]
(Rattus norvegicus)
phospho-PLN [sarcoplasmic reticulum membrane]
(Bos taurus)
phospho-PLN [sarcoplasmic reticulum membrane]
(Canis familiaris)
phospho-PLN [sarcoplasmic reticulum membrane]
(Gallus gallus)
phospho-PLN [sarcoplasmic reticulum membrane]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 16
Coordinate
16
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
ENSEMBL
ENST00000357525
,
ENSP00000350132
OpenTargets
ENSG00000198523
HPA
ENSG00000198523-PLN
PRO
P26678
Pharos - Targets
P26678
Orphanet
PLN
HMDB Protein
HMDBP02625
PDB
1ZLL
,
7E11
,
2HYN
,
6Y40
,
1PLP
,
7E12
,
7E0Z
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92838 EDA
1
EDA [plasma membrane]
(R-HSA-5667156)
0.886
11
UniProt:Q8N661 TMEM86B
1
TMEM86B [endoplasmic reticulum membrane]
(R-HSA-8874443)
0.556
3
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
3
UniProt:Q8IWU4 SLC30A8
2
SLC30A8 [Golgi membrane]
(R-HSA-9817561)
SLC30A8 [secretory granule membrane]
(R-HSA-437106)
0.556
3
UniProt:O60883 GPR37L1
1
GPR37L1 [plasma membrane]
(R-HSA-5336178)
0.556
3
UniProt:Q9H2K0 MTIF3
1
MTIF3 [mitochondrial matrix]
(R-HSA-5368284)
0.556
3
UniProt:Q16623 STX1A
5
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.556
3
UniProt:Q3SXY8 ARL13B
8
PolyUb-Misfolded ARL13B [lysosomal lumen]
(R-HSA-9660004)
PolyUb-Misfolded ARL13B [cytosol]
(R-HSA-9641129)
Ub-Misfolded ARL13B [cytosol]
(R-HSA-9641119)
Misfolded ARL13B [cytosol]
(R-HSA-9640110)
Misfolded ARL13B [cilium]
(R-HSA-9640116)
ARL13B [cilium]
(R-HSA-5618181)
PolyUb-Misfolded ARL13B [late endosome lumen]
(R-HSA-9659986)
ARL13B [plasma membrane]
(R-HSA-9716787)
0.556
3
UniProt:Q7Z5P4 HSD17B13
1
HSD17B13 [cytosol]
(R-HSA-8862029)
0.556
3
UniProt:O15342 ATP6V0E1
3
ATP6V0E1 [endosome membrane]
(R-HSA-912582)
ATP6V0E1 [phagocytic vesicle membrane]
(R-HSA-1222533)
ATP6V0E1 [lysosomal membrane]
(R-HSA-9640180)
0.556
3
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