NCOA1(868-1441) binds PAX3(1-319)

Stable Identifier
R-HSA-5579018
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
NCOA1:PAX3 oncogene causes rhabdomyosarcoma
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

A chromosomal aberration involving the nuclear receptor coactivator NCOA1 and paired box protein Pax-3 (PAX3) is a cause of rhabdomyosarcoma (RMS). Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. RMS is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children (Wachtel et al. 2004).

Literature References
PubMed ID Title Journal Year
15313887 Gene expression signatures identify rhabdomyosarcoma subtypes and detect a novel t(2;2)(q35;p23) translocation fusing PAX3 to NCOA1

Wachtel, M, Dettling, M, Koscielniak, E, Stegmaier, S, Treuner, J, Simon-Klingenstein, K, Bühlmann, P, Niggli, FK, Schäfer, BW

Cancer Res. 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created