NCOA2(869-1464) binds KAT6A(1-1118)

Stable Identifier
R-HSA-5579023
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
NCOA2:KAT6A fusion protein causes acute myeloid leukemias
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Chromosomal aberrations involving nuclear receptor coactivator 2 (NCOA2) and histone acetyltransferase KAT6A (KAT6A aka MOZ) may be a cause of acute myeloid leukemias. Inversion inv8(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation (Carapeti et al. 1998).

Literature References
PubMed ID Title Journal Year
9558366 A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia

Carapeti, M, Aguiar, RC, Goldman, JM, Cross, NC

Blood 1998
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created