PROCR binds Protein C

Stable Identifier
R-HSA-5591052
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
EPCR binds Protein C
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Physiological activation of protein C on the endothelial cell surface requires the binding of protein C to the endothelial protein C receptor PROCR (EPCR) as well as binding of thrombin to thrombomodulin (TM) (Stavenuiter et al. 2013). PROCR binding to protein C (Fukudome & Esmon 1994) augments by at least 5-fold the effect of thrombin-thrombomodulin on the rate of protein C activation (Stearns-Kurosawa et al. 1996, Taylor et al. 2001).

Literature References
PubMed ID Title Journal Year
11238108 Endothelial cell protein C receptor plays an important role in protein C activation in vivo

Taylor, FB, Peer, GT, Lockhart, MS, Ferrell, G, Esmon, CT

Blood 2001
Participants
Participant Of
This event is regulated
Orthologous Events
Authored
Reviewed
Created