Reactome | TLR3 P554S [endosome membrane]

TLR3 P554S [endosome membrane]

Stable Identifier

R-HSA-5602428

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

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Literature References

PubMed ID	Title	Journal	Year
17872438	TLR3 deficiency in patients with herpes simplex encephalitis Zhang, SY, Jouanguy, E, Ugolini, S, Smahi, A, Elain, G, Romero, P, Segal, D, Sancho-Shimizu, V, Lorenzo, L, Puel, A, Picard, C, Chapgier, A, Plancoulaine, S, Titeux, M, Cognet, C, von Bernuth, H, Ku, CL, Casrouge, A, Zhang, XX, Barreiro, L, Leonard, J, Hamilton, C, Lebon, P, Héron, B, Vallée, L, Quintana-Murci, L, Hovnanian, A, Rozenberg, F, Vivier, E, Geissmann, F, Tardieu, M, Abel, L, Casanova, JL	Science	2007

External Reference Information

External Reference

UniProt:O15455 TLR3

Gene Names

TLR3

Chain

signal peptide:1-23, chain:24-904

Reference Genes

BioGPS Gene:7098 TLR3

COSMIC (genes):TLR3 TLR3

CTD Gene:7098 TLR3

dbSNP Gene:7098 TLR3

ENSEMBL:ENSG00000164342 TLR3

HGNC:11849 TLR3

KEGG:hsa:7098 TLR3

Monarch:7098 TLR3

NCBI Gene:7098 TLR3

OMIM:603029 TLR3

UCSC:O15455 TLR3

Reference Transcript

Other Identifiers

11730296_a_at

16972993

206271_PM_at

206271_at

239587_PM_at

239587_at

242667_PM_at

242667_at

2754936

2754938

2754939

2754943

2754944

2754945

2754946

2754947

2754948

2754949

2754950

2754951

2754952

2754953

2754954

2754955

2754956

2754957

2754958

2754959

2754960

2754961

2754962

2754963

2754964

2754965

2754966

2754972

33488_at

7098

79848_at

80052_i_at

80054_r_at

8098611

A_23_P29922

A_32_P171793

A_32_P49054

GE476559

GE59525

GO:0000139

GO:0000165

GO:0001774

GO:0002224

GO:0002376

GO:0002684

GO:0002730

GO:0003723

GO:0003725

GO:0004888

GO:0005515

GO:0005737

GO:0005765

GO:0005768

GO:0005769

GO:0005783

GO:0005789

GO:0005886

GO:0006355

GO:0006952

GO:0006954

GO:0006972

GO:0007165

GO:0007250

GO:0007254

GO:0008584

GO:0009597

GO:0009615

GO:0010008

GO:0010628

GO:0016020

GO:0030163

GO:0032481

GO:0032722

GO:0032727

GO:0032728

GO:0032729

GO:0032735

GO:0032755

GO:0032757

GO:0032760

GO:0034138

GO:0034139

GO:0034343

GO:0034346

GO:0035458

GO:0036020

GO:0038023

GO:0038187

GO:0042742

GO:0042802

GO:0043065

GO:0043123

GO:0043161

GO:0043330

GO:0043331

GO:0044389

GO:0045087

GO:0045671

GO:0045766

GO:0045944

GO:0046330

GO:0050729

GO:0051607

GO:0060907

GO:0071260

GO:0071346

GO:0071360

GO:0071466

GO:0090594

GO:0097191

GO:0097527

GO:0098542

GO:0098586

GO:0141124

GO:1900017

HMNXSV003003562

Hs.145926.0.A1_3p_at

Hs.201600.0.A1_3p_at

ILMN_1689578

ILMN_2155708

PH_hs_0002558

TC04000912.hg

TC04002368.hg

g4507530_3p_at

Participates

as a member of

TLR3 variants [endosome membrane] (Homo sapiens)

Other forms of this molecule

TLR3 [endosome membrane]

TLR3 [Golgi membrane]

TLR3 [endolysosome membrane]

TLR3 [endoplasmic reticulum membrane]

TLR3 E746* [endosome membrane]

Modified Residues

Name

L-proline 554 replaced with L-serine

Coordinate

554

PsiMod

L-proline removal [MOD:01645]

A protein modification that effectively removes or replaces an L-proline.

L-serine residue [MOD:00025]

A protein modification that effectively converts a source amino acid residue to L-serine.

Cross References

RefSeq

XP_016864066.1, NP_003256.1

Guide to Pharmacology - Targets

1753

OpenTargets

ENSG00000164342

ENSEMBL

ENSP00000513676, ENST00000504367, ENSP00000296795, ENST00000508051, ENSG00000164342, ENSP00000423684, ENSP00000513668, ENST00000512264, ENST00000296795, ENSP00000513677, ENST00000698354

HPA

ENSG00000164342-TLR3

GeneCards

TLR3

PRO

O15455

Pharos - Targets

O15455

Orphanet

TLR3

GlyGen

O15455

PDB

8YHT, 2MK9, 7WVJ, 1ZIW, 3ULU, 3ULV, 2A0Z, 7WV5, 7WV3, 8YHU, 7WVE, 7WV4, 5GS0, 9LSJ, 9LSI, 9LSH, 2MKA, 7WVF, 7C76, 8AR1

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15455 TLR3	6	TLR3 [endosome membrane] (R-HSA-2000341) TLR3 [Golgi membrane] (R-HSA-1678955) TLR3 [endolysosome membrane] (R-HSA-167941) TLR3 [endoplasmic reticulum membrane] (R-HSA-1679057) TLR3 P554S [endosome membrane] (R-HSA-5602428) TLR3 E746* [endosome membrane] (R-HSA-5602730)	0.744	5
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.524	2
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276)	0.463	2
UniProt:Q7L0X0 TRIL			0.463	2
UniProt:P11226 MBL2	1	MBL2 [extracellular region] (R-HSA-166674)	0.463	2