TLR3 P554S [endosome membrane]

Stable Identifier
R-HSA-5602428
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Icon
TLR3 P554S [endosome membrane] icon
TLR3 P554S [endosome membrane] icon
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
17872438 TLR3 deficiency in patients with herpes simplex encephalitis

Hovnanian, A, Abel, L, Casrouge, A, von Bernuth, H, Lebon, P, Elain, G, Zhang, XX, Vallée, L, Lorenzo, L, Barreiro, L, Leonard, J, Plancoulaine, S, Quintana-Murci, L, Cognet, C, Rozenberg, F, Romero, P, Sancho-Shimizu, V, Smahi, A, Chapgier, A, Geissmann, F, Héron, B, Hamilton, C, Ku, CL, Jouanguy, E, Ugolini, S, Titeux, M, Puel, A, Picard, C, Zhang, SY, Vivier, E, Segal, D, Casanova, JL, Tardieu, M

Science 2007
External Reference Information
External Reference
UniProt:O15455 TLR3
Gene Names
TLR3
Chain
signal peptide:1-23, chain:24-904
Reference Genes
BioGPS Gene:7098 TLR3
COSMIC (genes):TLR3 TLR3
CTD Gene:7098 TLR3
dbSNP Gene:7098 TLR3
ENSEMBL:ENSG00000164342 TLR3
ENSEMBL_homo_sapiens_GENE:ENSG00000164342.14 TLR3
HGNC:11849 TLR3
KEGG Gene (Homo sapiens):7098 TLR3
Monarch:7098 TLR3
NCBI Gene:7098 TLR3
OMIM:603029 TLR3
UCSC:O15455 TLR3
Reference Transcript
Other Identifiers
11730296_a_at
16972993
206271_PM_at
206271_at
239587_PM_at
239587_at
242667_PM_at
242667_at
2754939
2754943
2754944
2754945
2754946
2754947
2754948
2754949
2754950
2754951
2754952
2754953
2754954
2754955
2754956
2754957
2754958
2754959
2754960
2754961
2754962
2754963
2754964
2754972
33488_at
7098
79848_at
80052_i_at
80054_r_at
8098611
A_23_P29922
A_32_P171793
A_32_P49054
GE476559
GE59525
GO:0000139
GO:0000165
GO:0001774
GO:0002224
GO:0002376
GO:0002730
GO:0003723
GO:0003725
GO:0004888
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005769
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0006351
GO:0006355
GO:0006952
GO:0006954
GO:0006955
GO:0006972
GO:0007165
GO:0007250
GO:0007252
GO:0007254
GO:0008584
GO:0009597
GO:0009615
GO:0010008
GO:0010628
GO:0012501
GO:0016020
GO:0022414
GO:0023052
GO:0030154
GO:0030312
GO:0031012
GO:0031410
GO:0032481
GO:0032722
GO:0032727
GO:0032728
GO:0032729
GO:0032735
GO:0032755
GO:0032757
GO:0032760
GO:0034138
GO:0034343
GO:0034346
GO:0035458
GO:0036020
GO:0036211
GO:0038023
GO:0038187
GO:0042742
GO:0042802
GO:0043065
GO:0043123
GO:0043226
GO:0043330
GO:0043331
GO:0045087
GO:0045671
GO:0045766
GO:0045944
GO:0046330
GO:0048856
GO:0050729
GO:0051607
GO:0060089
GO:0060907
GO:0071260
GO:0071346
GO:0071360
GO:0071466
GO:0090594
GO:0097191
GO:0097527
GO:0098542
GO:0098586
GO:1900017
GO:1901224
HMNXSV003003562
Hs.145926.0.A1_3p_at
Hs.201600.0.A1_3p_at
ILMN_1689578
ILMN_2155708
PH_hs_0002558
TC04000912.hg
TC04002368.hg
g4507530_3p_at
Participates
as a member of
Other forms of this molecule
TLR3 E746* [endosome membrane]
TLR3 [endoplasmic reticulum membrane]
TLR3 [endolysosome membrane]
TLR3 [Golgi membrane]
TLR3 [endosome membrane]
Modified Residues
Name
L-proline 554 replaced with L-serine
Coordinate
554
PsiMod
L-proline removal [MOD:01645]
A protein modification that effectively removes or replaces an L-proline.
L-serine residue [MOD:00025]
A protein modification that effectively converts a source amino acid residue to L-serine.
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
HPA
GeneCards
Ensembl
PRO
Pharos - Targets
Orphanet
PDB
Interactors (5)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:O15455 TLR3  6 0.744 5
 UniProt:P27986 PIK3R1  16 0.524 2
 UniProt:P11226 MBL2  1 0.463 2
 UniProt:Q7L0X0 TRIL      0.463 2
 UniProt:P12931 SRC  6 0.463 2
Cite Us!