Reactome | MyD88 E65del [cytosol]

MyD88 E65del [cytosol]

Stable Identifier

R-HSA-5602598

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Literature References

PubMed ID	Title	Journal	Year
23002119	IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4-, MyD88-, and TIRAP- but not UNC-93B-deficient patients Alcais, A, Bonnet, M, Reynaud, CA, Weller, S, Camcioglu, Y, Roifman, C, Zitnik, SE, Cerutti, A, Hoarau, C, Israel, L, Vasconcelos, J, Weill, JC, Delagreverie, H, Rodrigo, C, Arkwright, PD, Chrabieh, M, Issekutz, AC, Rodriguez-Gallego, C, Garty, BZ, Puel, A, Picard, C, Meffre, E, Zhang, SY, Maródi, L, Casanova, JL	Blood	2012

External Reference Information

External Reference

UniProt:Q99836 MYD88

Gene Names

MYD88

Chain

chain:1-296

Reference Genes

BioGPS Gene:4615 MYD88

COSMIC (genes):MYD88 MYD88

CTD Gene:4615 MYD88

dbSNP Gene:4615 MYD88

ENSEMBL:ENSG00000172936 MYD88

ENSEMBL:ENSG00000172936.17 MYD88

HGNC:7562 MYD88

KEGG Gene (Homo sapiens):4615 MYD88

Monarch:4615 MYD88

NCBI Gene:4615 MYD88

OMIM:602170 MYD88

UCSC:Q99836 MYD88

Reference Transcript

Other Identifiers

11720623_a_at

11720624_a_at

11747538_a_at

11747539_x_at

16939127

209124_PM_at

209124_at

2617564

2617565

2617566

2617567

2617570

2617572

2617574

2617576

2617577

2617578

38369_at

4615

8078729

A_14_P101666

A_14_P118253

A_23_P362659

A_23_P92140

GE59370

GO:0002238

GO:0002269

GO:0002283

GO:0002376

GO:0002755

GO:0003824

GO:0005102

GO:0005121

GO:0005123

GO:0005149

GO:0005515

GO:0005634

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006909

GO:0006915

GO:0006954

GO:0007165

GO:0007166

GO:0007249

GO:0007254

GO:0008063

GO:0009615

GO:0009682

GO:0009986

GO:0010008

GO:0010243

GO:0010467

GO:0010468

GO:0010628

GO:0012501

GO:0014004

GO:0014070

GO:0014075

GO:0016064

GO:0016071

GO:0016192

GO:0019209

GO:0019221

GO:0019897

GO:0022008

GO:0023052

GO:0030154

GO:0031234

GO:0031410

GO:0031663

GO:0032481

GO:0032494

GO:0032496

GO:0032675

GO:0032680

GO:0032722

GO:0032731

GO:0032740

GO:0032747

GO:0032755

GO:0032757

GO:0032760

GO:0032991

GO:0034142

GO:0034158

GO:0035325

GO:0042127

GO:0042742

GO:0042802

GO:0042832

GO:0043123

GO:0043200

GO:0043226

GO:0043588

GO:0043621

GO:0045087

GO:0045471

GO:0045944

GO:0046330

GO:0048661

GO:0048856

GO:0048870

GO:0050671

GO:0050727

GO:0050830

GO:0051092

GO:0051607

GO:0060090

GO:0060337

GO:0060907

GO:0065003

GO:0070498

GO:0070555

GO:0070935

GO:0070944

GO:0070976

GO:0071222

GO:0071260

GO:0071310

GO:0090557

GO:0098542

GO:0098772

GO:0140052

GO:0140096

GO:0140097

GO:0140104

GO:0140657

GO:0140674

GO:1900017

GO:1900227

GO:1902622

GO:2000338

GO:2000341

HMNXSV003055007

ILMN_1738523

PH_hs_0004695

TC03000187.hg

U70451_at

g1763090_3p_at

Participates

as a candidate of

MyD88 variants [cytosol] (Homo sapiens)

Other forms of this molecule

MyD88 R196C [cytosol]

MyD88 E52del [cytosol]

MyD88 L93P [cytosol]

MyD88 S34Y [cytosol]

MYD88 [endosome membrane]

MYD88 [plasma membrane]

MYD88 [cytosol]

Modified Residues

Name

Deletion of residues 65 to 65

Cross References

RefSeq

NP_001166037.1, NP_001166040.1, NP_002459.2, NP_001166039.1

OpenTargets

ENSG00000172936

GeneCards

Q99836

HPA

ENSG00000172936-MYD88

Ensembl

ENSP00000498360, ENSP00000391753, ENSG00000172936, ENSP00000499012, ENSP00000497991, ENST00000421516, ENST00000650112, ENST00000650905, ENST00000417037, ENSP00000401399, ENST00000651800

PRO

Q99836

Pharos - Targets

Q99836

Orphanet

18435

PDB

3MOP, 7BER, 2Z5V, 7BEQ, 4DOM, 2JS7, 4EO7, 6I3N, 7L6W

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99836 MYD88	8	MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [endosome membrane] (R-HSA-975123) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059)	0.958	40
UniProt:Q9NWZ3 IRAK4	9	IRAK4 R12C [cytosol] (R-HSA-5602511) IRAK4 Q293TER [cytosol] (R-HSA-5602426) IRAK4 E402TER [cytosol] (R-HSA-5602517) p-T342,T345,S346-IRAK4 [cytosol] (R-HSA-446649) IRAK4 [endosome membrane] (R-HSA-975167) p-T342,T345,S346-IRAK4 [endosome membrane] (R-HSA-975149) IRAK4 [plasma membrane] (R-HSA-937051) p-T342,T345,S346-IRAK4 [plasma membrane] (R-HSA-936957) IRAK4 [cytosol] (R-HSA-166081)	0.922	15
UniProt:P58753 TIRAP	2	TIRAP [cytosol] (R-HSA-166141) p-4Y-TIRAP [plasma membrane] (R-HSA-2201321)	0.819	8
UniProt:O43791 SPOP	1	SPOP [nucleoplasm] (R-HSA-5635035)	0.786	7
UniProt:O00206 TLR4	2	TLR4 [endosome membrane] (R-HSA-2201285) 2xN4GlycoAsn-TLR4 [plasma membrane] (R-HSA-166045)	0.758	4
UniProt:O60603 TLR2	3	TLR2 [plasma membrane] (R-HSA-9637646) TLR2 [secretory granule membrane] (R-HSA-6804777) TLR2 [plasma membrane] (R-HSA-167992)	0.737	4
UniProt:O14836 TNFRSF13B	1	TAC1 [plasma membrane] (R-HSA-5668752)	0.692	12
UniProt:P51617 IRAK1	14	p-S376,T387-IRAK1 [cytosol] (R-HSA-446687) K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-S,T-IRAK1 [cytosol] (R-HSA-3149574) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) IRAK1 [endosome membrane] (R-HSA-975127) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) IRAK1 [plasma membrane] (R-HSA-937045) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) IRAK1 [cytosol] (R-HSA-446639)	0.641	3
UniProt:Q6SZW1 SARM1			0.622	5
UniProt:P10599 TXN	4	2xHC-TXN [nucleoplasm] (R-HSA-9617733) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [cytosol] (R-HSA-66000)	0.602	4
UniProt:Q8NF50 DOCK8	1	DOCK8 [cytosol] (R-HSA-1011619)	0.576	3
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.573	3
UniProt:P13682 ZNF35			0.556	3
UniProt:Q69FE3 Q69FE3			0.556	5
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q6IQ16 SPOPL	1	SPOPL [nucleoplasm] (R-HSA-5635036)	0.556	3
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.543	3
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.543	3
UniProt:Q93009 USP7	2	USP7 [cytosol] (R-HSA-8853511) USP7 [nucleoplasm] (R-HSA-3215278)	0.543	3
UniProt:Q9UBN7 HDAC6	4	HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.524	6
UniProt:Q9UGK3 STAP2	2	p-Y250-STAP2 [plasma membrane] (R-HSA-8848079) STAP2 [cytosol] (R-HSA-8848028)	0.524	3
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.462	8

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