Reactome | MyD88 E65del [cytosol]

MyD88 E65del [cytosol]

Stable Identifier

R-HSA-5602598

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Literature References

PubMed ID	Title	Journal	Year
23002119	IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4-, MyD88-, and TIRAP- but not UNC-93B-deficient patients Weller, S, Bonnet, M, Delagreverie, H, Israel, L, Chrabieh, M, Maródi, L, Rodriguez-Gallego, C, Garty, BZ, Roifman, C, Issekutz, AC, Zitnik, SE, Hoarau, C, Camcioglu, Y, Vasconcelos, J, Rodrigo, C, Arkwright, PD, Cerutti, A, Meffre, E, Zhang, SY, Alcais, A, Puel, A, Casanova, JL, Picard, C, Weill, JC, Reynaud, CA	Blood	2012

External Reference Information

External Reference

UniProt:Q99836 MYD88

Gene Names

MYD88

Chain

chain:1-296

Reference Genes

BioGPS Gene:4615 MYD88

COSMIC (genes):MYD88 MYD88

CTD Gene:4615 MYD88

dbSNP Gene:4615 MYD88

ENSEMBL:ENSG00000172936 MYD88

HGNC:7562 MYD88

KEGG Gene (Homo sapiens):4615 MYD88

Monarch:4615 MYD88

NCBI Gene:4615 MYD88

OMIM:602170 MYD88

UCSC:Q99836 MYD88

Reference Transcript

Other Identifiers

0001400128

11720623_a_at

11720624_a_at

11747538_a_at

11747539_x_at

16939127

209124_at

2617564

2617565

2617566

2617567

2617570

2617572

2617574

2617576

2617577

2617578

2JS7

2Z5V

38369_at

3MOP

4615

4DOM

4EO7

8078729

9104

A0A0A0MS70

A0A0A0MSI9

A0A3B3ITY3

A0A3F2YP85

A0A494C0J8

A_14_P101666

A_14_P118253

A_23_P362659

A_23_P92140

AAB49967

AAC50954

AAH13589

AAP36040

AB446470

AK296570

AK296716

AK298650

AK298666

AP006309

BAG55247

BAG59190

BAG59306

BAG60822

BAG60834

BC013589

BI524129

BT007376

CAB009104

CH471055

EAW64521

ENSG00000172936

ENSP00000379625

ENSP00000389979

ENSP00000390565

ENSP00000391753

ENSP00000417848

ENSP00000498360

ENST00000396334

ENST00000396334.8

ENST00000421516

ENST00000421516.2

ENST00000424893

ENST00000424893.6

ENST00000443433

ENST00000443433.6

ENST00000495303

ENST00000495303.6

ENST00000650905

EntrezGene:4615

EntrezGene:MYD88

g1763090_3p_at

GE59370

GO:0002224

GO:0002376

GO:0002755

GO:0003674

GO:0005123

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0006810

GO:0006909

GO:0006915

GO:0006950

GO:0006954

GO:0007165

GO:0007166

GO:0008063

GO:0008150

GO:0008219

GO:0009056

GO:0009058

GO:0010008

GO:0010628

GO:0016192

GO:0031410

GO:0032481

GO:0032740

GO:0032747

GO:0032755

GO:0032757

GO:0034162

GO:0034641

GO:0034655

GO:0035325

GO:0042742

GO:0042802

GO:0042832

GO:0043066

GO:0043123

GO:0043226

GO:0043621

GO:0045087

GO:0050727

GO:0050830

GO:0051092

GO:0060337

GO:0070498

GO:0070555

GO:0070935

GO:0070976

GO:0071222

GO:0071260

GO:0140052

GO:1900017

H0Y4G9

HGNC:7562

ILMN_1738523

IPR000157

IPR000488

IPR011029

IPR017281

IPR034249

IPR035897

LRG_157

LRG_157t1

MIM:153600

MIM:602170

MIM:612260

MYD88

MYD88-201

MYD88-204

MYD88-205

MYD88-206

MYD88-211

MYD88-214

NM_001172566

NM_001172567

NM_001172568

NM_001172569

NM_002468

NP_001166037

NP_001166038

NP_001166039

NP_001166040

NP_002459

PF00531

PF01582

PH_hs_0004695

SM00005

SM00255

TC03000187.hg

U70451

U70451_at

U84408

UPI000012FAD4

UPI00003E4796

UPI00005A71AE

UPI0003F05720

UPI0003F057AC

Participant Of

hasCandidate

MyD88 variants [cytosol]

Other forms of this molecule

MYD88 [cytosol]

MYD88 [plasma membrane]

MYD88 [cytosol]

MYD88 [endosome membrane]

MyD88 S34Y [cytosol]

MyD88 L93P [cytosol]

MyD88 E52del [cytosol]

MyD88 R196C [cytosol]

Modified Residues

Name

Deletion of residues 65 to 65

Cross References

RefSeq

NP_002459.2, NP_001166037.1, NP_001166040.1, NP_001166039.1

OpenTargets

ENSG00000172936

GeneCards

Q99836

PRO

Q99836

Orphanet

18435

PDB

4EO7, 4DOM, 2JS7, 2Z5V, 3MOP

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99836 MYD88	9	MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-193946) MYD88 [cytosol] (R-HSA-166059) MYD88 [endosome membrane] (R-HSA-975123) MyD88 E65del [cytosol] (R-HSA-5602598) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 R196C [cytosol] (R-HSA-5602329)	0.951	38
UniProt:Q9NWZ3 IRAK4	9	IRAK4 Q293TER [cytosol] (R-HSA-5602426) IRAK4 R12C [cytosol] (R-HSA-5602511) IRAK4 E402TER [cytosol] (R-HSA-5602517) p-T342,T345,S346-IRAK4 [cytosol] (R-HSA-446649) IRAK4 [endosome membrane] (R-HSA-975167) p-T342,T345,S346-IRAK4 [endosome membrane] (R-HSA-975149) IRAK4 [plasma membrane] (R-HSA-937051) p-T342,T345,S346-IRAK4 [plasma membrane] (R-HSA-936957) IRAK4 [cytosol] (R-HSA-166081)	0.917	16
UniProt:P58753 TIRAP	2	TIRAP [cytosol] (R-HSA-166141) p-4Y-TIRAP [plasma membrane] (R-HSA-2201321)	0.819	8
UniProt:O43791 SPOP	1	SPOP [nucleoplasm] (R-HSA-5635035)	0.786	7
UniProt:O00206 TLR4	2	2xN4GlycoAsn-TLR4 [plasma membrane] (R-HSA-166045) TLR4 [endosome membrane] (R-HSA-2201285)	0.758	4
UniProt:O60603 TLR2	3	TLR2 [secretory granule membrane] (R-HSA-6804777) TLR2 [plasma membrane] (R-HSA-9637646) TLR2 [plasma membrane] (R-HSA-167992)	0.737	4
UniProt:O14836 TNFRSF13B	1	TAC1 [plasma membrane] (R-HSA-5668752)	0.692	12
UniProt:P51617 IRAK1	14	p-S,T-IRAK1 [cytosol] (R-HSA-3149574) K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-S376,T387-IRAK1 [cytosol] (R-HSA-446687) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) IRAK1 [cytosol] (R-HSA-446639) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) IRAK1 [plasma membrane] (R-HSA-937045) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) IRAK1 [endosome membrane] (R-HSA-975127)	0.641	3
UniProt:Q6SZW1 SARM1			0.622	5
UniProt:P10599 TXN	4	TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [cytosol] (R-HSA-66000)	0.602	4
UniProt:Q8NF50 DOCK8	1	DOCK8 [cytosol] (R-HSA-1011619)	0.576	3
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.573	3
UniProt:P38340 NTM1			0.556	3
UniProt:Q69FE3 Q69FE3			0.556	5
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.543	3
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.543	3
UniProt:P84022 SMAD3	12	p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 S425F [cytosol] (R-HSA-8944158) p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 S425C [cytosol] (R-HSA-3308499)	0.543	3
UniProt:Q9UBN7 HDAC6	5	HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [cytosol] (R-HSA-9646404) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.524	6
UniProt:Q9UGK3 STAP2	2	STAP2 [cytosol] (R-HSA-8848028) p-Y250-STAP2 [plasma membrane] (R-HSA-8848079)	0.524	3
UniProt:Q8NFW5 DMBX1			0.488	2
UniProt:P13682 ZNF35			0.488	2
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.488	2
UniProt:Q96HA8 NTAQ1			0.488	2
UniProt:Q6IQ16 SPOPL	1	SPOPL [nucleoplasm] (R-HSA-5635036)	0.488	2
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.462	8