Activated protein C is released from PROCR

Stable Identifier
R-HSA-5603467
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Activated protein C (APC) can either dissociate from PROCR to exert its anticoagulant activity, or remain bound to PROCR where it influences multiple direct cellular activities. Dissociation of APC from PROCR allows APC to associate with other cell membrane surface molecules, various microparticles, or lipoproteins (e.g., high-density lipoprotein). As an anticoagulant, APC cleaves the activated cofactors Va (fVa) and VIIIa (fVIIIa), yielding inactivated cofactors, fVi and fVIIIi. This proteolytic inactivation is enhanced by protein cofactors (e.g., protein S, factor V) and lipids cofactors (e.g., phosphatidylserine, cardiolipin, glucosylceramide, or HDL).

Literature References
PubMed ID Title Journal Year
17635713 Activated protein C

Griffin, JH, Fernández, JA, Gale, AJ, Mosnier, LO

J. Thromb. Haemost. 2007
Participants
Participant Of
Orthologous Events
Authored
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