Expression of ANGPTL4

Stable Identifier
R-HSA-560473
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
Synonyms
Induction of Angiopoietin-related protein 4 (ANGPTL4) Expression
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Expression of ANGPTL4
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The ANGPTL4 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

The PPARG:RXRA heterodimer bound to fatty acids activates transcription of the ANGPTL4 gene. The PPARG:RXRA heterodimer binds the promoter of the ANGPTL4 gene.

Literature References
PubMed ID Title Journal Year
19710929 Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human

Hooiveld, G, Muller, M, Rakhshandehroo, M, Kersten, S

PLoS One 2009
19934321 Activating peroxisome proliferator-activated receptor gamma mutant promotes tumor growth in vivo by enhancing angiogenesis

Wang, M, Tian, L, Ojeifo, JO, Zhou, J, Pestell, RG, Casimiro, MC, Liang, B, Wang, C, Hyslop, T

Cancer Res 2009
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Regulator
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Authored
May, B  (2010-03-23)
Reviewed
Sethi, JK  (2011-02-10)
Kersten, S  (2009-06-08)
D'Eustachio, P  (2009-05-27)
Created
May, B  (2010-03-24)
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