Soluble PROCR binds activated protein C

Stable Identifier
R-HSA-5606996
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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A soluble form of PROCR (sEPCR) fully retains the ability to bind Protein C and Activated protein C (Kurosawa et al. 1997). This form increases up to 5-fold in patients with sepsis or systemic lupus erythematosus (Kurosawa et al. 1998), either from vascular injury or through a regulated proteolytic release of soluble receptor (Gu et al. 2000). sEPCR inhibits protein C activation over large vessel endothelium in culture, reflecting competition between the soluble and cell surface forms of PROCR (Liaw et al. 2000).

Literature References
PubMed ID Title Journal Year
9218519 Identification of functional endothelial protein C receptor in human plasma

Kurosawa, S, Stearns-Kurosawa, DJ, Hidari, N, Esmon, CT

J. Clin. Invest. 1997
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