Reactome | Active NIK [cytosol]

Active NIK [cytosol]

Stable Identifier

R-HSA-5607646

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Active MAP3K14, Mitogen-activated protein kinase kinase kinase 14 ecNumber2.7.11.25/ecNumber, NF-kB inducing kinase

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External Reference Information

External Reference

UniProt:Q99558 MAP3K14

Gene Names

MAP3K14, NIK

Chain

chain:1-947

Reference Genes

BioGPS Gene:9020 MAP3K14

COSMIC (genes):MAP3K14 MAP3K14

CTD Gene:9020 MAP3K14

dbSNP Gene:9020 MAP3K14

ENSEMBL:ENSG00000006062 MAP3K14

HGNC:6853 MAP3K14

KEGG:hsa:9020 MAP3K14

Monarch:9020 MAP3K14

NCBI Gene:9020 MAP3K14

OMIM:604655 MAP3K14

UCSC:Q99558 MAP3K14

Reference Transcript

Other Identifiers

11724902_a_at

11724903_a_at

16845876

205192_PM_at

205192_at

3759702

3759703

3759705

3759706

3759707

3759708

3759709

3759710

3759712

3759713

3759717

3759718

3759719

3759720

3759721

3759722

3759730

3759732

3759733

3759734

3759735

3759736

3759737

3759740

3759741

3759749

3759752

8016194

9020

974_at

A_23_P207319

GE60277

GO:0000165

GO:0001650

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004709

GO:0005515

GO:0005524

GO:0005654

GO:0005737

GO:0005829

GO:0006468

GO:0006955

GO:0007249

GO:0016740

GO:0038061

GO:0043226

GO:0043231

GO:0051607

GO:0071260

GO:0098542

GO:0106310

GO:0140096

HMNXSV003030142

ILMN_1724070

PH_hs_0025776

TC17001598.hg

Y10256_at

g4505396_3p_at

p29173

p33461

Participates

as an input of

Active NIK phosphorylates IKKA dimer (Homo sapiens)

as an output of

Activation of NIK (Homo sapiens)

as a component of

Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)

Other forms of this molecule

MAP3K14 [cytosol]

p-MAP3K14 [cytosol]

K48polyUb-NIK [cytosol]

p-T559-MAP3K14 [cytosol]

Inferred To

Ghost homologue of Active NIK [cytosol] (Drosophila melanogaster)

MAP3K14 [cytosol] (Bos taurus)

MAP3K14 [cytosol] (Canis familiaris)

MAP3K14 [cytosol] (Gallus gallus)

MAP3K14 [cytosol] (Mus musculus)

MAP3K14 [cytosol] (Saccharomyces cerevisiae)

MAP3K14 [cytosol] (Sus scrofa)

MAP3K14 [cytosol] (Xenopus tropicalis)

Map3k14 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_003945.2, XP_011523743.1

Guide to Pharmacology - Targets

2074

OpenTargets

ENSG00000006062

ENSEMBL

ENSP00000480974, ENST00000344686, ENST00000617331, ENSP00000482657, ENSP00000478552, ENST00000376926

ZINC - Substances

M3K14_HUMAN

ZINC - Biogenic

M3K14_HUMAN

ZINC target

Q99558

PRO

Q99558

GlyGen

Q99558

PDB

6Z1T, 4DN5, 8YHW, 6WPP, 4IDV, 4IDT, 6Z1Q, 4G3D

HPA

ENSG00000006062-MAP3K14

Pharos - Targets

Q99558

Orphanet

MAP3K14

ZINC - Predictions - Purchasable

M3K14_HUMAN

HMDB Protein

HMDBP01177

Interactors (46)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15111 CHUK	4	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615) p-Y187,Y198-CHUK [cytosol] (R-HSA-9861501)	0.946	14
UniProt:Q13114 TRAF3	4	K63polyUb-TRAF3 [cytosol] (R-HSA-936402) TRAF3 [cytosol] (R-HSA-914241) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 R118W [cytosol] (R-HSA-5602321)	0.918	10
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.904	7
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.813	6
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.758	6
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.749	9
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.744	5
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.744	5
UniProt:P27708 CAD	1	CAD [cytosol] (R-HSA-73452)	0.669	3
UniProt:Q9Y5L4 TIMM13	2	TIMM13 [mitochondrial intermembrane space] (R-HSA-1307781) 4xHC-TIMM13 [mitochondrial intermembrane space] (R-HSA-1252199)	0.643	4
UniProt:Q00653 NFKB2	6	NFKB2(1-454) [nucleoplasm] (R-HSA-177674) NFKB2(1-454) [cytosol] (R-HSA-168144) p-7S-p100 [cytosol] (R-HSA-5607629) K48-polyUb-p-7S-p100 [cytosol] (R-HSA-5607636) NFKB2(1-900) [cytosol] (R-HSA-2677931) monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol] (R-HSA-4755500)	0.643	4
UniProt:P62280 RPS11	2	RPS11 [cytosol] (R-HSA-72327) RPS11 [nucleoplasm] (R-HSA-6791212)	0.564	3
UniProt:P62277 RPS13	2	RPS13 [cytosol] (R-HSA-72331) RPS13 [nucleoplasm] (R-HSA-6791198)	0.564	3
UniProt:P52272 HNRNPM	1	HNRNPM [nucleoplasm] (R-HSA-71949)	0.564	3
UniProt:P62847 RPS24	2	RPS24 [cytosol] (R-HSA-72355) RPS24 [nucleoplasm] (R-HSA-6791186)	0.564	2
UniProt:P62917 RPL8	3	RPL8 [cytosol] (R-HSA-72490) RPL8 [nucleoplasm] (R-HSA-9630985) 3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976)	0.564	3
UniProt:Q3ZCQ8 TIMM50	1	TIMM50 [mitochondrial inner membrane] (R-HSA-1252070)	0.564	2
UniProt:P39023 RPL3	1	RPL3 [cytosol] (R-HSA-72448)	0.564	3
UniProt:P18124 RPL7	1	RPL7 [cytosol] (R-HSA-72486)	0.564	3
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.564	3
UniProt:P32969 RPL9	1	RPL9 [cytosol] (R-HSA-72492)	0.564	3
UniProt:Q96L21 RPL10L	1	RPL10L [cytosol] (R-HSA-8868799)	0.564	3
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.564	3
UniProt:Q02878 RPL6	1	RPL6 [cytosol] (R-HSA-72484)	0.564	3
UniProt:P83731 RPL24	1	RPL24 [cytosol] (R-HSA-72434)	0.564	3
UniProt:P62910 RPL32	1	RPL32 [cytosol] (R-HSA-72456)	0.564	3
UniProt:P62906 RPL10A	1	RPL10A [cytosol] (R-HSA-72404)	0.564	3
UniProt:P62829 RPL23	1	RPL23 [cytosol] (R-HSA-72430)	0.564	3
UniProt:P17066 HSPA6	5	HSPA6 [cytosol] (R-HSA-3371521) HSPA6 [nucleoplasm] (R-HSA-5252088) HSPA6 [ficolin-1-rich granule lumen] (R-HSA-6801512) HSPA6 [extracellular region] (R-HSA-6806500) HSPA6 [secretory granule lumen] (R-HSA-6801472)	0.564	3
UniProt:Q07020 RPL18	1	RPL18 [cytosol] (R-HSA-72420)	0.564	3
UniProt:P27635 RPL10	1	RPL10 [cytosol] (R-HSA-72402)	0.564	3
UniProt:P26373 RPL13	1	RPL13 [cytosol] (R-HSA-72410)	0.564	3
UniProt:P50914 RPL14	1	RPL14 [cytosol] (R-HSA-72414)	0.564	3
UniProt:P62269 RPS18	2	RPS18 [cytosol] (R-HSA-72341) RPS18 [nucleoplasm] (R-HSA-6798701)	0.564	2
UniProt:P62424 RPL7A	1	RPL7A [cytosol] (R-HSA-72488)	0.564	3
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.564	3
UniProt:P61353 RPL27	1	RPL27 [cytosol] (R-HSA-72440)	0.564	3
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) proHRAS [cytosol] (R-HSA-9647765) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.556	3
UniProt:Q60680-2 CHUK			0.544	3
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.536	2
UniProt:Q9Y5A9 YTHD2			0.527	2
UniProt:Q7L2E3 DHX30			0.527	2
UniProt:Q58FG0 HS905			0.527	2
UniProt:Q9Y5J9 TIMM8B	2	TIMM8B [mitochondrial intermembrane space] (R-HSA-1307790) 4xHC-TIMM8B [mitochondrial intermembrane space] (R-HSA-1252067)	0.527	2
UniProt:O60220 TIMM8A	2	TIMM8A [mitochondrial intermembrane space] (R-HSA-1307780) 4xHC-TIMM8A [mitochondrial intermembrane space] (R-HSA-1252065)	0.527	2
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978)	0.499	2

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