26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex

Stable Identifier
R-HSA-5607724
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Following ubiquitination Ikappa B-alpha (IKBA) is rapidly degraded by 26S-proteasome, allowing NF-kB to translocate into the nucleus where it activates gene transcription (Spencer et al. 1999).

Literature References
PubMed ID Title Journal Year
9362451 The carboxy-terminus of I kappaB alpha determines susceptibility to degradation by the catalytic core of the proteasome

Kroll, M, Conconi, M, Desterro, MJ, Marin, A, Thomas, D, Friguet, B, Hay, RT, Virelizier, JL, Arenzana-Seisdedos, F, Rodriguez, MS

Oncogene 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created