BCL10 binds CARD9

Stable Identifier
R-HSA-5607733
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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BCL10 binds CARD9
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B-cell lymphoma/leukemia 10 (BCL10) is the downstream signaling partner of CARD9 and it interacts selectively with the CARD activation domain of CARD9. BCL10 functions as an adaptor between the effector IKK complex and the proximal signaling complexes that interact with CARD9 (Bertin et al. 2000).
Literature References
PubMed ID Title Journal Year
11053425 CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B

Bertin, J, Guo, Y, Wang, L, Srinivasula, SM, Jacobson, MD, Poyet, JL, Merriam, S, Du, MQ, Dyer, MJ, Robison, KE, DiStefano, PS, Alnemri, ES

J. Biol. Chem. 2000
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Orthologous Events
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BCL10 binds CARD9 (Sus scrofa)
BCL10 binds CARD9 (Xenopus tropicalis)
Authored
Garapati, P V  (2014-07-14)
Reviewed
Geijtenbeek, TB  (2014-09-02)
Created
Garapati, P V  (2014-07-14)
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