MALT1 oligomerizes

Stable Identifier
R-HSA-5607736
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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After binding BCL10, MALT1 also undergoes oligomerization. Like traditional caspases, MALT1 also becomes activated through the formation of oligomers. Once the CARD9-BCL10-MALT1 (CBM) signalosome is assembled, MALT1 functions as the effector protein and mediates activation of the IKK complex (McAllister-Lucas & Lucas 2008).

Literature References
PubMed ID Title Journal Year
24074955 Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly

Qiao, Q, Yang, C, Zheng, C, Fontán, L, David, L, Yu, X, Bracken, C, Rosen, M, Melnick, A, Egelman, EH, Wu, H

Mol. Cell 2013
21966355 Oligomeric structure of the MALT1 tandem Ig-like domains

Qiu, L, Dhe-Paganon, S

PLoS ONE 2011
11262391 Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway

Lucas, PC, Yonezumi, M, Inohara, N, McAllister-Lucas, LM, Abazeed, ME, Chen, FF, Yamaoka, S, Seto, M, Nunez, G

J. Biol. Chem. 2001
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