p52:RELB translocates from cytosol to nucleus

Stable Identifier
R-HSA-5607741
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Following 26S-proteasomal processing, NFKB2 p52:RELB dimer is translocated from cytosol into the nucleus where it stimulates expression of target genes (Lin & Karin 2003). Dectin-1 induced RELB-p52 triggers the transcription of chemokines C-C motif chemokine 17 (CCL17) and CCL22 and repression of interleukin 12B (IL12B) transcription (Gringhuis et al. 2009).

Literature References
PubMed ID Title Journal Year
8921937 Differential nuclear localization of p50, p52, and RelB proteins in human accessory cells of the immune response in situ

Feuillard, J, Körner, M, Israël, A, Vassy, J, Raphael, M

Eur. J. Immunol. 1996
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