CLEC7A (Dectin-1) induces NFAT activation

Stable Identifier
R-HSA-5607763
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CLEC7A (Dectin-1) signals through the classic calcineurin/NFAT pathway through Syk activation phospholipase C-gamma 2 (PLCG2) leading to increased soluble IP3 (inositol trisphosphate). IP3 is able to bind endoplasmic Ca2+ channels, resulting in an influx of Ca2+ into the cytoplasm. This increase in calcium concentration induces calcineurin activation and consequently, dephosphorylation of NFAT and its translocation into the nucleus, triggering gene transcription and extracellular release of Interleukin-2 (Plato et al. 2013, Goodridge et al. 2007, Mourao-Sa et al. 2011).

Literature References
PubMed ID Title Journal Year
17312158 Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells

Goodridge, HS, Simmons, RM, Underhill, DM

J. Immunol. 2007
22611159 NFAT control of innate immunity

Fric, J, Zelante, T, Wong, AY, Mertes, A, Yu, HB, Ricciardi-Castagnoli, P

Blood 2012
21728173 CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses

Mourão-Sá, D, Robinson, MJ, Zelenay, S, Sancho, D, Chakravarty, P, Larsen, R, Plantinga, M, Van Rooijen, N, Soares, MP, Lambrecht, B, Reis e Sousa, C

Eur. J. Immunol. 2011
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