Reactome | GLI2 [ciliary tip]

GLI2 [ciliary tip]

Stable Identifier

R-HSA-5610363

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ciliary tip

Synonyms

Zinc finger protein GLI2, GLI2_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P10070 GLI2

Gene Names

GLI2, THP

Chain

chain:1-1586

Reference Genes

BioGPS Gene:2736 GLI2

COSMIC (genes):GLI2 GLI2

CTD Gene:2736 GLI2

dbSNP Gene:2736 GLI2

ENSEMBL:ENSG00000074047 GLI2

HGNC:4318 GLI2

KEGG:hsa:2736 GLI2

Monarch:2736 GLI2

NCBI Gene:2736 GLI2

OMIM:165230 GLI2

UCSC:P10070 GLI2

Reference Transcript

RefSeq:NM_005270.4 GLI2

Other Identifiers

11743688_at

11748709_a_at

11750395_a_at

11751794_a_at

11762325_at

11763578_a_at

11763579_x_at

11763611_a_at

11763612_x_at

1200_at

16885153

207034_PM_s_at

207034_s_at

208057_PM_s_at

208057_s_at

228537_PM_at

228537_at

2503375

2503376

2503379

2503380

2503381

2503399

2503405

2503406

2503411

2503412

2503413

2503414

2503416

2503417

2503418

2503421

2503422

2503423

2503424

2503425

2503426

2503427

2503428

2503429

2503430

2503431

2503432

2503433

2503434

2503435

2503436

2503437

2503438

2503439

2503440

2503441

2503469

2736

34456_s_at

50974_at

8044933

A_14_P107717

A_23_P209246

A_23_P500034

A_33_P3358457

A_33_P3358462

A_33_P3358469

D14827_at

GE53148

GO:0000122

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0001228

GO:0001501

GO:0001649

GO:0001701

GO:0001822

GO:0002009

GO:0002062

GO:0002076

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005929

GO:0005930

GO:0006355

GO:0006357

GO:0007224

GO:0007389

GO:0007411

GO:0007418

GO:0007442

GO:0007507

GO:0008270

GO:0008283

GO:0008284

GO:0008589

GO:0009952

GO:0009953

GO:0009954

GO:0010467

GO:0016020

GO:0016607

GO:0021508

GO:0021513

GO:0021517

GO:0021522

GO:0021696

GO:0021775

GO:0021776

GO:0021904

GO:0021915

GO:0021965

GO:0021983

GO:0022414

GO:0030154

GO:0030182

GO:0030324

GO:0030879

GO:0030902

GO:0031069

GO:0031490

GO:0031514

GO:0032331

GO:0033089

GO:0035295

GO:0042475

GO:0042733

GO:0043066

GO:0043226

GO:0043565

GO:0045666

GO:0045740

GO:0045879

GO:0045893

GO:0045944

GO:0046872

GO:0048566

GO:0048589

GO:0048646

GO:0048666

GO:0048754

GO:0048856

GO:0050673

GO:0050679

GO:0060032

GO:0060322

GO:0060513

GO:0060603

GO:0060831

GO:0071407

GO:0072089

GO:0090103

GO:0097542

GO:0097546

GO:0140110

GO:1990788

GO:1990837

GO:1990841

GO:2000648

HMNXSV003043881

Hs.293790.0.A1_3p_at

ILMN_1727577

PH_hs_0006130

TC02000764.hg

TC02003538.hg

g13518230_3p_a_at

g439899_3p_a_at

Participates

as a member of

GLI1,2,3 [ciliary tip] (Homo sapiens)

Other forms of this molecule

GLI2 [ciliary base]

2p-GLI2 [nucleoplasm]

p-GLI2 [nucleoplasm]

p-GLI2 [ciliary tip]

GLI2 [cytosol]

ub-p11S-GLI2 [ciliary base]

p11S-GLI2 [ciliary base]

p8S-GLI2 [ciliary base]

p4S-GLI2 [ciliary base]

ub-2p-GLI2 [nucleoplasm]

Inferred To

gli2a [ciliary tip] (Danio rerio)

Gli2 [ciliary tip] (Mus musculus)

Gli2 [ciliary tip] (Rattus norvegicus)

ci [ciliary tip] (Drosophila melanogaster)

gli2 [ciliary tip] (Xenopus tropicalis)

GLI2 [ciliary tip] (Bos taurus)

GLI2 [ciliary tip] (Canis familiaris)

GLI2 [ciliary tip] (Gallus gallus)

GLI2 [ciliary tip] (Sus scrofa)

Cross References

RefSeq

NP_005261.2

OpenTargets

ENSG00000074047

ENSEMBL

ENSP00000390436, ENST00000452319

HPA

ENSG00000074047-GLI2

ZINC - Substances

GLI2_HUMAN

ZINC - Biogenic

GLI2_HUMAN

ZINC target

P10070

PRO

P10070

Pharos - Targets

P10070

Orphanet

GLI2

GlyGen

P10070

ZINC - Predictions - Purchasable

GLI2_HUMAN

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.576	4
UniProt:Q2M1P5 KIF7	1	KIF7 [ciliary tip] (R-HSA-5610395)	0.569	3
UniProt:Q9UMX1 SUFU	3	SUFU [ciliary base] (R-HSA-5610424) SUFU [cytosol] (R-HSA-445455) SUFU [ciliary tip] (R-HSA-5610426)	0.569	3
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.558	4
UniProt:Q15796 SMAD2	20	Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009185) p-S465,S467-SMAD2 [cytosol] (R-HSA-3009186) SMAD2 [cytosol] (R-HSA-3006353) p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009189) Ub,p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-9773843) SMAD2 [nucleoplasm] (R-HSA-3006352) p-S250-SMAD2 [cytosol] (R-HSA-9731121) SMAD2 Q429* [cytosol] (R-HSA-9668727) SMAD2 S467P [cytosol] (R-HSA-3304375) SMAD2 L315* [cytosol] (R-HSA-9668725) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 S296* [cytosol] (R-HSA-9668729)	0.462	2