Reactome | SUFU [ciliary tip]

SUFU [ciliary tip]

Stable Identifier

R-HSA-5610426

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ciliary tip

Synonyms

Suppressor of fused homolog, SUFU_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q9Y234 LIPT1

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External Reference Information

External Reference

UniProt:Q9UMX1 SUFU

Gene Names

SUFU, UNQ650/PRO1280

Chain

chain:1-484

Reference Genes

BioGPS Gene:51684 SUFU

COSMIC (genes):SUFU SUFU

CTD Gene:51684 SUFU

dbSNP Gene:51684 SUFU

ENSEMBL:ENSG00000107882 SUFU

HGNC:16466 SUFU

KEGG:hsa:51684 SUFU

Monarch:51684 SUFU

NCBI Gene:51684 SUFU

OMIM:607035 SUFU

UCSC:Q9UMX1 SUFU

Reference Transcript

Participates

as an output of

as a component of

Other forms of this molecule

SUFU [ciliary base]

SUFU [cytosol]

Inferred To

Sufu [ciliary tip] (Mus musculus)

Sufu [ciliary tip] (Rattus norvegicus)

Su(fu) [ciliary tip] (Drosophila melanogaster)

sufu [ciliary tip] (Danio rerio)

sufu [ciliary tip] (Xenopus tropicalis)

SUFU [ciliary tip] (Bos taurus)

SUFU [ciliary tip] (Canis familiaris)

SUFU [ciliary tip] (Gallus gallus)

SUFU [ciliary tip] (Sus scrofa)

Cross References

OpenTargets

ENSG00000107882

ENSEMBL

ENST00000423559, ENSP00000358918, ENSG00000107882, ENSP00000358915, ENSP00000411597, ENST00000369899, ENST00000369902

GeneCards

SUFU

HPA

ENSG00000107882-SUFU

PRO

Q9UMX1

Pharos - Targets

Q9UMX1

Orphanet

SUFU

PDB

4BLD, 4KMD, 4BL8, 4KM9, 4BLB, 4BL9, 4KMH, 4KM8, 4BLA, 1M1L

Interactors (54)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08151 GLI1	9	GLI1 [ciliary tip] (R-HSA-5610360) GLI1 [ciliary base] (R-HSA-5610357) p-GLI1 [nucleoplasm] (R-HSA-5635042) 2p-GLI1 [nucleoplasm] (R-HSA-5635057) p-GLI1 [ciliary tip] (R-HSA-5635040) GLI1 [cytosol] (R-HSA-445457) pS-GLI1 [ciliary base] (R-HSA-5610497) ub-pS-GLI1 [ciliary base] (R-HSA-5610514) ub-GLI1 [cytosol] (R-HSA-5635833)	0.968	27
UniProt:Q9BV97 ZNF747	1	ZNF747 [nucleoplasm] (R-HSA-2586596)	0.848	8
UniProt:Q96H86 ZNF764	1	ZNF764 [nucleoplasm] (R-HSA-3343766)	0.847	9
UniProt:P10071 GLI3	13	GLI3R [nucleoplasm] (R-HSA-5610371) GLI3R [cytosol] (R-HSA-5610369) ub-p13S-GLI3 [ciliary base] (R-HSA-5610506) p13S-GLI3 [ciliary base] (R-HSA-5610485) p10S-GLI3 [ciliary base] (R-HSA-5610454) p6S-GLI3 [ciliary base] (R-HSA-5610492) GLI3 [ciliary base] (R-HSA-5610365) GLI3 [ciliary tip] (R-HSA-5610367) p-GLI3 [nucleoplasm] (R-HSA-5635051) 2p-GLI3 [nucleoplasm] (R-HSA-5635052) p-GLI3 [ciliary tip] (R-HSA-5635048) GLI3 [cytosol] (R-HSA-206085) ub-2p-GLI3 [nucleoplasm] (R-HSA-5635060)	0.773	5
UniProt:Q13515 BFSP2			0.742	6
UniProt:Q96D15 RCN3			0.703	5
UniProt:Q9NWS9-2 ZNF446			0.666	4
UniProt:Q7Z353 HDX			0.666	4
UniProt:Q8TBC5 ZSC18			0.666	4
UniProt:P30307 CDC25C	8	p-S198-CDC25C [nucleoplasm] (R-HSA-156668) CDC25C [cytosol] (R-HSA-157879) p-S198-CDC25C [cytosol] (R-HSA-8981697) CDC25C [nucleoplasm] (R-HSA-69741) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) p-S216-CDC25C [cytosol] (R-HSA-75003) p-S191-CDC25C [nucleoplasm] (R-HSA-6802968) p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654)	0.643	3
UniProt:Q86YD7 F90A1			0.643	3
UniProt:O14753 OVOL1			0.641	3
UniProt:P10070 GLI2	11	GLI2 [ciliary tip] (R-HSA-5610363) GLI2 [ciliary base] (R-HSA-5610361) 2p-GLI2 [nucleoplasm] (R-HSA-5635055) p-GLI2 [nucleoplasm] (R-HSA-5635047) p-GLI2 [ciliary tip] (R-HSA-5635044) GLI2 [cytosol] (R-HSA-445451) ub-p11S-GLI2 [ciliary base] (R-HSA-5610501) p11S-GLI2 [ciliary base] (R-HSA-5610471) p8S-GLI2 [ciliary base] (R-HSA-5610494) p4S-GLI2 [ciliary base] (R-HSA-5610487) ub-2p-GLI2 [nucleoplasm] (R-HSA-5635059)	0.569	3
UniProt:Q12968 NFATC3	3	p-S265-NFATC3 [nucleoplasm] (R-HSA-2025988) p-S265-NFATC3 [cytosol] (R-HSA-2685614) p-13S-NFATC3 [cytosol] (R-HSA-2025920)	0.564	2
UniProt:Q15915 ZIC1	1	ZIC1 [nucleoplasm] (R-HSA-9731648)	0.556	3
UniProt:Q92876 KLK6			0.556	3
UniProt:Q96GZ6 S41A3			0.556	3
UniProt:Q86V38 Q86V38			0.556	3
UniProt:O95678 KRT75	1	KRT75 [cytosol] (R-HSA-6809652)	0.556	3
UniProt:O00746 NME4	1	NME4 [mitochondrial inner membrane] (R-HSA-60026)	0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q9UJ55 MAGL2			0.556	3
UniProt:Q9P2A4 ABI3			0.556	3
UniProt:Q86VQ0 LCA5			0.556	3
UniProt:Q0D2J5 ZN763			0.556	3
UniProt:Q8N4C7 STX19			0.556	3
UniProt:Q53ET0 CRTC2	1	CRTC2 [nucleoplasm] (R-HSA-8931951)	0.556	5
UniProt:Q96JM7-2 L3MBTL3			0.556	3
UniProt:O43186 CRX			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q9NRI5-2 DISC1			0.556	3
IntAct:EBI-22313194 CCSB ORF ID			0.556	3
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.556	3
UniProt:Q9Y3S2 ZN330			0.556	3
UniProt:P51114-2 FXR1			0.556	3
UniProt:Q8NC26 ZNF114	1	ZNF114 [nucleoplasm] (R-HSA-975026)	0.556	3
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:Q8NEA6 GLIS3			0.553	3
UniProt:O14978 ZNF263	1	ZNF263 [nucleoplasm] (R-HSA-1027393)	0.553	2
UniProt:Q9NPA3 MID1IP1	1	MID1IP1 [cytosol] (R-HSA-8867328)	0.547	3
UniProt:Q9NRP7 STK36			0.536	3
UniProt:P12644 BMP4	4	BMP4(20-408) [extracellular region] (R-HSA-2396280) p-BMP4 [endoplasmic reticulum lumen] (R-HSA-8956944) BMP4 [endoplasmic reticulum lumen] (R-HSA-8956775) BMP4 [extracellular region] (R-HSA-8858573)	0.527	3
UniProt:Q7Z6J8 UBE3D	1	UBE3D [cytosol] (R-HSA-8851647)	0.527	2
UniProt:P30837 ALDH1B1	1	ALDH1B1 [mitochondrial matrix] (R-HSA-5696097)	0.527	2
UniProt:O14771 ZNF213	1	ZNF213 [nucleoplasm] (R-HSA-1027351)	0.527	3
UniProt:Q92611 EDEM1	1	EDEM1 [endoplasmic reticulum quality control compartment] (R-HSA-381083)	0.527	2
UniProt:Q1X8D7 LRC36			0.527	2
UniProt:O60293 ZFC3H1	1	ZFC3H1 [nucleoplasm] (R-HSA-9930046)	0.527	3
UniProt:Q16822 PCK2	1	PCK2 [mitochondrial matrix] (R-HSA-372815)	0.527	3
UniProt:Q9Y466 NR2E1	1	NR2E1 [nucleoplasm] (R-HSA-376207)	0.527	2
UniProt:O95157 NXPH3			0.527	3
UniProt:Q9Y234 LIPT1	1	LIPT1 [mitochondrial matrix] (R-HSA-6792623)	0.527	2
UniProt:Q7Z412 PEX26	2	PEX26 [cytosol] (R-HSA-9603779) PEX26 [peroxisomal membrane] (R-HSA-9033092)	0.508	2
UniProt:Q0VGT2 Gli2	13	phospho-Gli2 [nucleoplasm] (R-MMU-5635059) ub-p11S-Gli2 [cytosol] (R-MMU-5610503) p11S-Gli2 [cytosol] (R-MMU-5610476) p8S-Gli2 [cytosol] (R-MMU-5610496) p4S-Gli2 [cytosol] (R-MMU-5610489) Gli2 [cytosol] (R-MMU-5610376) Gli2 [nucleoplasm] (R-MMU-3900178) Gli2 [cytosol] (R-MMU-445451) phospho-Gli2 [ciliary tip] (R-MMU-5635044) phospho-Gli2 [nucleoplasm] (R-MMU-5635047) phospho-Gli2 [nucleoplasm] (R-MMU-5635055) Gli2 [ciliary base] (R-MMU-5610361) Gli2 [ciliary tip] (R-MMU-5610363)	0.463	3