Reactome | TTC21B [cilium]

TTC21B [cilium]

Stable Identifier

R-HSA-5610430

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cilium

Synonyms

IFT139, IFT A 139, THM1

Locations in the PathwayBrowser for interactor UniProt:P18206 VCL

Expand all

External Reference Information

External Reference

UniProt:Q7Z4L5 TTC21B

Gene Names

TTC21B, IFT139, KIAA1992, Nbla10696

Chain

chain:1-1316

Reference Genes

BioGPS Gene:79809 TTC21B

COSMIC (genes):TTC21B TTC21B

CTD Gene:79809 TTC21B

dbSNP Gene:79809 TTC21B

ENSEMBL:ENSG00000123607 TTC21B

ENSEMBL_homo_sapiens_GENE:ENSG00000123607.16 TTC21B

HGNC:25660 TTC21B

KEGG Gene (Homo sapiens):79809 TTC21B

Monarch:79809 TTC21B

NCBI Gene:79809 TTC21B

OMIM:612014 TTC21B

UCSC:Q7Z4L5 TTC21B

Reference Transcript

RefSeq:NM_024753.4 TTC21B

Other Identifiers

11735944_x_at

11753947_a_at

16904580

16904588

220064_PM_at

220064_at

2585233

2585235

2585237

2585238

2585247

2585248

2585249

2585250

2585251

2585252

2585253

2585254

2585255

2585256

2585261

2585262

2585263

2585264

2585265

2585266

2585267

2585272

2585273

2585274

2585278

2585279

2585280

2585282

2585284

2585286

2585287

2585290

2585291

2585294

2585295

2585296

2585297

2585298

2585299

2585300

2585304

2585305

2585306

2585308

2585309

2585311

74021_at

79809

8056426

90225_at

A_23_P5422

A_24_P111511

GE87142

GO:0003682

GO:0005515

GO:0005737

GO:0005856

GO:0005929

GO:0006351

GO:0006355

GO:0006357

GO:0007018

GO:0007224

GO:0008589

GO:0010628

GO:0021549

GO:0021591

GO:0021702

GO:0021798

GO:0023052

GO:0030154

GO:0030900

GO:0030991

GO:0035721

GO:0042995

GO:0043226

GO:0044782

GO:0048856

GO:0060020

GO:0060271

GO:0061512

GO:0090263

GO:0097499

GO:0097542

GO:1903999

GO:1905799

HMNXSV003016208

HMNXSV003038503

HMNXSV003057157

ILMN_2217955

PH_hs_0024466

PH_hs_0035887

TC02002495.hg

g13376083_3p_at

Participates

as a component of

as an input of

Assembly of IFT A complex (Homo sapiens)

as a member of

retrograde IFT regulators of Hh [cilium] (Homo sapiens)

Other forms of this molecule

TTC21B [ciliary tip]

Inferred To

ift-139 [cilium] (Caenorhabditis elegans)

Ttc21b [cilium] (Mus musculus)

Ttc21b [cilium] (Rattus norvegicus)

ttc21b [cilium] (Xenopus tropicalis)

TTC21B [cilium] (Bos taurus)

TTC21B [cilium] (Canis familiaris)

TTC21B [cilium] (Gallus gallus)

TTC21B [cilium] (Sus scrofa)

Cross References

RefSeq

NP_079029.3

OpenTargets

ENSG00000123607

HPA

ENSG00000123607-TTC21B

GeneCards

Q7Z4L5

Ensembl

ENST00000681952, ENSP00000506276, ENSP00000506400, ENSP00000243344, ENST00000680888, ENST00000243344, ENSG00000123607

PRO

Q7Z4L5

Pharos - Targets

Q7Z4L5

Orphanet

19838

PDB

8BBE, 8BBG, 8FGW

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75386 TULP3	1	TULP3 [cilium] (R-HSA-5610445)	0.789	8
UniProt:Q9HBG6 IFT122	2	IFT122 [ciliary tip] (R-HSA-5625346) IFT122 [cilium] (R-HSA-5610379)	0.704	5
UniProt:Q96FT9 IFT43	2	IFT43 [cilium] (R-HSA-5617619) IFT43 [ciliary tip] (R-HSA-5625348)	0.704	8
UniProt:Q8NEZ3 WDR19	2	WDR19 [cilium] (R-HSA-5610446) WDR19 [ciliary tip] (R-HSA-5625347)	0.638	3
UniProt:Q96RY7 IFT140	2	IFT140 [cilium] (R-HSA-5610382) IFT140 [ciliary tip] (R-HSA-5625345)	0.638	3
UniProt:Q9P2L0 WDR35	2	WDR35 [ciliary tip] (R-HSA-5625351) WDR35 [cilium] (R-HSA-5610448)	0.611	4
UniProt:Q14183 DOC2A			0.527	3
UniProt:Q96FT9-2 IFT43			0.527	3
UniProt:Q9HBV2 SACA1			0.527	2
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.508	2
UniProt:Q9Y262 EIF3L	1	EIF3L [cytosol] (R-HSA-377452)	0.508	2
UniProt:P18206 VCL	8	VCL(1-811)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713472) VCL(1-811)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713480) VCL(95 kDa) [cytosol] (R-HSA-9861471) VCL [specific granule lumen] (R-HSA-6799711) VCL [secretory granule lumen] (R-HSA-6801010) VCL [extracellular region] (R-HSA-350736) VCL [ficolin-1-rich granule lumen] (R-HSA-6800985) VCL [cytosol] (R-HSA-350753)	0.508	2