OCT2 mediates tubular secretion of organic cations in the kidney

Stable Identifier
R-HSA-561054
Type
Reaction [transition]
Species
Homo sapiens
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The human gene SLC22A2 encodes the organic cation transporter OCT2. It is expressed in a variety of tissues, especially the kidney and placenta. OCT2 can mediate the reversible transport of a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN) and 4-(4-(dimethylamino)styryl)-N-methylpyridinium (Gorboulev et al. 1997). Pharmaceuticals that up-regulate OCT2 in the kidney can increase the renal excretion of cationic drugs. The transport activity of OCT2 was decreased upon co-expression of regulatory solute carrier protein family 1 member 1 (RSC1A1, aka RS1). RSC1A1 exhibits glucose-dependent, short-term inhibition of OCT2 by inhibiting the release of vesicles from the trans-Golgi network (Veyhl et al. 2006).

Literature References
PubMed ID Title Journal Year
16788146 RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1

Veyhl, M, Keller, T, Gorboulev, V, Vernaleken, A, Koepsell, H

Am. J. Physiol. Renal Physiol. 2006
9260930 Cloning and characterization of two human polyspecific organic cation transporters

Gorboulev, V, Ulzheimer, JC, Akhoundova, A, Ulzheimer-Teuber, I, Karbach, U, Quester, S, Baumann, C, Lang, F, Busch, AE, Koepsell, H

DNA Cell Biol 1997
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
organic cation transmembrane transporter activity of OCT2 [plasma membrane]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
Cross References
Rhea
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Reviewed
Created