Reactome | OAT2 and OAT4 mediate transport of sulphate conjugates

OAT2 and OAT4 mediate transport of sulphate conjugates

Stable Identifier

R-HSA-561059

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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OAT2 and OAT4 mediate transport of sulphate conjugates

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The human gene SLC22A7 encodes organic anion transporter 2 (OAT2) and is highly expressed in the liver and kidney (Sun W et al, 2001; Kobayashi Y et al, 2005). The human gene SLC22A11 encodes organic anion transporter 4 (OAT4) which is highly expressed in the placenta and kidney (Cha SH et al, 2000; Ekaratanawong S et al, 2004). Both of these transporters mediate the influx of sulfate conjugates with antiport of dicarboxylic acid. OAT2 is classified as both a transporter of organic anions and sulphate conjugates.

Literature References

PubMed ID	Title	Journal	Year
11327718	Isolation of a family of organic anion transporters from human liver and kidney Wu, RR, Sun, W, van Poelje, PD, Erion, MD	Biochem Biophys Res Commun	2001
15901346	Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]) Ohshiro, N, Kobayashi, Y, Yamamoto, T, Kohyama, N, Sakai, R, Ohbayashi, M	J Pharm Pharmacol	2005
15037815	Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules Miyazaki, H, Endou, H, Noshiro, R, Jutabha, P, Ekaratanawong, S, Anzai, N, Kanai, Y, Takeda, M, Sophasan, S	J Pharmacol Sci	2004
10660625	Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta Cha, SH, Endou, H, Yu, E, Kim, DK, Kusuhara, H, Kanai, Y, Sugiyama, Y, Kim, JY, Sekine, T	J Biol Chem	2000