Reactome: A Curated Pathway Database

PKA phosphorylates GLI2

Stable Identifier
R-HSA-5610717
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Despite sharing 44% amino acid identity with GLI3, only a small fraction of GLI2 appears to be processed to a repressor form in the absence of Hh signaling; the bulk of the protein is completely degraded in a phosphorylation- and proteasome-dependent manner (Pan et al, 2007; Pan et al, 2009; Pan and Wang, 2007). Degradation of GLI2 depends on phosphorylation of four consensus PKA sites in the C-terminal region. This phosphorylation primes GLI2 for subsequent phosphorylation by CK1 and GSK3, creating a binding site for betaTrCP and promoting its subsequent ubiquitination and degradation (Pan et al, 2006; Pan and Wang, 2007; Pan et al, 2009).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
cAMP-dependent protein kinase activity of PKA catalytic subunit [ciliary base] PKA catalytic subunit [ciliary base] cAMP-dependent protein kinase activity (0004691)
Inferred From