Reactome | CK1 phosphorylates p-GLI2

CK1 phosphorylates p-GLI2

Stable Identifier

R-HSA-5610718

Type

Reaction [transition]

Species

Homo sapiens

Compartment

ciliary base

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Phosphorylation by PKA primes GLI2 for subsequent phosphorylation at adjacent CK sites (Pan et al, 2006; Pan and Wang, 2007).

Literature References

PubMed ID	Title	Journal	Year
16611981	Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation Pan, Y, Bai, CB, Joyner, AL, Wang, B	Mol. Cell. Biol.	2006
17283082	A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome Pan, Y, Wang, B	J. Biol. Chem.	2007

Participants

Input

Output

Participant Of

hasEvent

Degradation of GLI2 by the proteasome

Catalyst Activity

Title

protein serine/threonine kinase activity of CSNK1A1 [cytosol]

Physical Entity

CSNK1A1 [cytosol]

Activity

protein serine/threonine kinase activity (0004674)

Inferred From

CK1 phosphorylates p-Gli2 (Mus musculus)

Authored

Rothfels, K (2014-05-07)

Reviewed

Liu, Y C (2014-08-01)

Created

Rothfels, K (2014-07-23)

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