Reactome | CK1 phosphorylates p-GLI2

Stable Identifier

R-HSA-5610718

Type

Reaction

Species

Homo sapiens

Compartment

ciliary base

Locations in the PathwayBrowser

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Summation

Phosphorylation by PKA primes GLI2 for subsequent phosphorylation at adjacent CK sites (Pan et al, 2006; Pan and Wang, 2007).

Literature References

PubMed ID	Title	Journal	Year
16611981	Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation	Mol. Cell. Biol.	2006
17283082	A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome	J. Biol. Chem.	2007

Participants

Input

Output

Participant Of

hasEvent

Catalyst Activity

Title

protein serine/threonine kinase activity of CSNK1A1 [cytosol]

Physical Entity

CSNK1A1 [cytosol]

Activity

protein serine/threonine kinase activity (0004674)

Inferred From

Authored

Rothfels, Karen, 2014-05-07

Reviewed

Liu, Yulu Cherry, 2014-08-01