Reactome: A Curated Pathway Database

PKA phosphorylates GLI3

Stable Identifier
R-HSA-5610720
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylation of GLI3 by PKA on up to six sites in the C-terminal region primes the protein for subsequent phosphorylation by CK1 and GSK3 and is required for the ubiquitin-mediated processing by the proteasome to yield the truncated repressor form (Tempe et al, 2006; Pan et al, 2006; Pan and Wang, 2007; Wang and Li, 2006). Processing of GLI3 is regulated in part by movement through the primary cilia, and disruption of intraflagellar transport abrogates processing (Wen et al, 2010)

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
cAMP-dependent protein kinase activity of PKA catalytic subunit [ciliary base] PKA catalytic subunit [ciliary base] cAMP-dependent protein kinase activity (0004691)
Orthologous Events