TULP3 is required for GPR161 localization in the cilium

Stable Identifier
R-HSA-5610725
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TULP3 and the retrograde complex IFT-A are required to recruit GPR161 to the cilium in the absence of Hh ligand (Mukhopadhyay et al, 2010; Mukhopadhyay et al, 2013; reviewed in Mukhopadhyay and Rohtagi, 2014). TULP3 is a negative regulator of Hh signaling and siRNA depletion of TULP3 reduces the ciliary accumulation of GPR161 (Norman et al, 2009; Patterson et al, 2009; Mukhopadhyay et al, 2010; Mukhopadhyay et al, 2013).

Literature References
PubMed ID Title Journal Year
20889716 TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

Mukhopadhyay, S, Wen, X, Chih, B, Nelson, CD, Lane, WS, Scales, SJ, Jackson, PK

Genes Dev. 2010
23332756 The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling

Mukhopadhyay, S, Wen, X, Ratti, N, Loktev, A, Rangell, L, Scales, SJ, Jackson, PK

Cell 2013
19223390 Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway

Patterson, VL, Damrau, C, Paudyal, A, Reeve, B, Grimes, DT, Stewart, ME, Williams, DJ, Siggers, P, Greenfield, A, Murdoch, JN

Hum. Mol. Genet. 2009
19286674 Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling

Norman, RX, Ko, HW, Huang, V, Eun, CM, Abler, LL, Zhang, Z, Sun, X, Eggenschwiler, JT

Hum. Mol. Genet. 2009
24845016 G-protein-coupled receptors, Hedgehog signaling and primary cilia

Mukhopadhyay, S, Rohatgi, R

Semin. Cell Dev. Biol. 2014
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created