Reactome | TULP3 is required for GPR161 localization in the cilium

TULP3 is required for GPR161 localization in the cilium

Stable Identifier

R-HSA-5610725

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cilium

ReviewStatus

5/5

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TULP3 is required for GPR161 localization in the cilium

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TULP3 and the retrograde complex IFT-A are required to recruit GPR161 to the cilium in the absence of Hh ligand (Mukhopadhyay et al, 2010; Mukhopadhyay et al, 2013; reviewed in Mukhopadhyay and Rohtagi, 2014). TULP3 is a negative regulator of Hh signaling and siRNA depletion of TULP3 reduces the ciliary accumulation of GPR161 (Norman et al, 2009; Patterson et al, 2009; Mukhopadhyay et al, 2010; Mukhopadhyay et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
23332756	The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling Mukhopadhyay, S, Wen, X, Ratti, N, Loktev, A, Rangell, L, Scales, SJ, Jackson, PK	Cell	2013
20889716	TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia Mukhopadhyay, S, Wen, X, Chih, B, Nelson, CD, Lane, WS, Scales, SJ, Jackson, PK	Genes Dev.	2010
19223390	Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway Patterson, VL, Damrau, C, Paudyal, A, Reeve, B, Grimes, DT, Stewart, ME, Williams, DJ, Siggers, P, Greenfield, A, Murdoch, JN	Hum. Mol. Genet.	2009
19286674	Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling Norman, RX, Ko, HW, Huang, V, Eun, CM, Abler, LL, Zhang, Z, Sun, X, Eggenschwiler, JT	Hum. Mol. Genet.	2009
24845016	G-protein-coupled receptors, Hedgehog signaling and primary cilia Mukhopadhyay, S, Rohatgi, R	Semin. Cell Dev. Biol.	2014