GPR161 promotes cAMP production in a G alpha(s)-dependent manner

Stable Identifier
R-HSA-5610727
Type
Reaction [transition]
Species
Homo sapiens
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cAMP is generated by the action of adenylate cyclases (reviewed in Sassone-Corsi, 2012). GPR161 is an orphan GPCR that has recently been identified as a negative regulator of Hh signaling that acts by increasing cellular cAMP levels in the absence of ligand. Overexpression of GPR161 increases cellular cAMP levels in a manner that depends on the G alpha s subunit, and depletion of GPR161 results in aberrant Hh signaling and a decrease in the ratio of processed GLI3R (Mukhopadhyay et al, 2013). These data suggest that GPR161 negatively regulates GLI processing in the absence of Hh signal by modulating PKA activity through cAMP levels (Mukhopadhyay et al, 2013; reviewed in Mukhopadhyay and Rohatgi, 2014).

Literature References
PubMed ID Title Journal Year
23332756 The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling

Mukhopadhyay, S, Wen, X, Ratti, N, Loktev, A, Rangell, L, Scales, SJ, Jackson, PK

Cell 2013
23209152 The cyclic AMP pathway

Sassone-Corsi, P

Cold Spring Harb Perspect Biol 2012
24845016 G-protein-coupled receptors, Hedgehog signaling and primary cilia

Mukhopadhyay, S, Rohatgi, R

Semin. Cell Dev. Biol. 2014
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Catalyst Activity
Title
adenylate cyclase activity of adenylate cyclases:Mg2+ [plasma membrane]
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This event is regulated
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Rhea
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