GSK3 phosphorylates p-GLI2

Stable Identifier
R-HSA-5610730
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Like GLI3, GLI2 has putative GSK3 sites that contribute to the proteasome-dependent degradation of the protein in the absence of Hh signal. Deletion of the GSK3 phosphorylation sites abrogates the interaction with beta-TrCP, stabilizes GLI2 protein and increases the expression of a GLI-dependent reporter, consistent with a role for GSK3 in promoting GLI2 degradation (Pan et al, 2006).

Literature References
PubMed ID Title Journal Year
16611981 Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

Pan, Y, Bai, CB, Joyner, AL, Wang, B

Mol. Cell. Biol. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of GSK3B [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed