Reactome: A Curated Pathway Database

GSK3 phosphorylates p-GLI2

Stable Identifier
R-HSA-5610730
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Like GLI3, GLI2 has putative GSK3 sites that contribute to the proteasome-dependent degradation of the protein in the absence of Hh signal. Deletion of the GSK3 phosphorylation sites abrogates the interaction with beta-TrCP, stabilizes GLI2 protein and increases the expression of a GLI-dependent reporter, consistent with a role for GSK3 in promoting GLI2 degradation (Pan et al, 2006).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of GSK3B [cytosol] GSK3B [cytosol] protein serine/threonine kinase activity (0004674)
Inferred From