KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules

Stable Identifier
R-HSA-5610733
Type
Reaction [binding]
Species
Homo sapiens
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KIF7, the human ortholog of Drosophila COS2, is a kinesin-4 motor protein that binds directly to the plus ends of axonemal microtubules and inhibits their growth in an ATP-dependent manner (He et al, 2014). KIF7 is required for the processing and activity of GLI in the absence of Hh signal, and KIF7 function depends on the primary cilium (Liem et al, 2009; Cheung et al, 2009; Endoh-Yamagami et al, 2009). KIF7 has been shown to bind to GLI3 and to SUFU and may act in part by promoting the transit of the GLI:SUFU complex through the primary cilium, which is required for GLI processing (Endoh-Yamagami et al, 2009; Maurya et al, 2013). How KIF7 itself is localized to the cilia tip is unknown, although localization depends on the KIF7 motor domain (Liem et al, 2009; He et al, 2014). KIF7 localization is further enhanced at the primary cilia tip in response to Hh signaling, as is also the case for GLI2, GLI3 and SUFU (He et al, 2014; Varjosalo et al, 2008; Haycraft et al, 2005; Wen et al, 2010; Qin et al, 2011; Tukachinsky et al, 2010).

Literature References
PubMed ID Title Journal Year
19666503 Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling

Liem, KF, He, M, Ocbina, PJ, Anderson, KV

Proc. Natl. Acad. Sci. U.S.A. 2009
24339784 Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo

Maurya, AK, Ben, J, Zhao, Z, Lee, RT, Niah, W, Ng, AS, Iyu, A, Yu, W, Elworthy, S, van Eeden, FJ, Ingham, PW

PLoS Genet. 2013
19592253 The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development

Endoh-Yamagami, S, Evangelista, M, Wilson, D, Wen, X, Theunissen, JW, Phamluong, K, Davis, M, Scales, SJ, Solloway, MJ, de Sauvage, FJ, Peterson, AS

Curr. Biol. 2009
21209331 Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

Qin, J, Lin, Y, Norman, RX, Ko, HW, Eggenschwiler, JT

Proc. Natl. Acad. Sci. U.S.A. 2011
16254602 Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

Haycraft, CJ, Banizs, B, Aydin-Son, Y, Zhang, Q, Michaud, EJ, Yoder, BK

PLoS Genet. 2005
19549984 The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling

Cheung, HO, Zhang, X, Ribeiro, A, Mo, R, Makino, S, Puviindran, V, Law, KK, Briscoe, J, Hui, CC

Sci Signal 2009
20154143 Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation

Wen, X, Lai, CK, Evangelista, M, Hongo, JA, de Sauvage, FJ, Scales, SJ

Mol. Cell. Biol. 2010
24952464 The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment

He, M, Subramanian, R, Bangs, F, Omelchenko, T, Liem, KF, Kapoor, TM, Anderson, KV

Nat. Cell Biol. 2014
18455992 Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling

Varjosalo, M, Björklund, M, Cheng, F, Syvänen, H, Kivioja, T, Kilpinen, S, Sun, Z, Kallioniemi, O, Stunnenberg, HG, He, WW, Ojala, P, Taipale, J

Cell 2008
20956384 A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes

Tukachinsky, H, Lopez, LV, Salic, A

J. Cell Biol. 2010
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