Reactome: A Curated Pathway Database

NUMB:ITCH bind and ubiquitnate GLI1

Stable Identifier
R-HSA-5610737
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

GLI1 is recruited to the NUMB:ITCH complex through a direct interaction with both proteins. Once recruited, GLI1 is ubiquitinated by ITCH and subsequently degraded by the proteasome. ITCH-mediated degradation of GLI1 does not depend on the Dc or Dn degrons required for interaction with beta-TrCP, but instead relies on a novel PPXYs/pSP degron of GLI1 (di Marcotullio et al, 2006, 2011; Huntzicker et al, 2006). How these two apparently parallel systems of GLI1 ubiquitination and degradation are coordinated is not yet clear.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
ubiquitin protein ligase activity of NUMB:ITCH [cytosol] NUMB:ITCH [cytosol] ubiquitin protein ligase activity (0061630)
Orthologous Events