Reactome: A Curated Pathway Database

SCF(beta-TrCP) ubiquitinates p-GLI2

Stable Identifier
R-HSA-5610745
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

GLI2 interacts directly with beta-TrCP and is polyubiquitinated in a phosphorylation-dependent manner. Binding and ubiquitination by beta-TrCP depends on 2 motifs located in the region of GLI2 phosphorylated by PKA, CK1 and GSK3 (Pan et al, 2006).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
ubiquitin-protein transferase activity of BTRC:CUL1:RBX1:SKP1 [cytosol] BTRC:CUL1:RBX1:SKP1 [cytosol] ubiquitin-protein transferase activity (0004842)
Inferred From