SCF(beta-TrCP) ubiquitinates p-GLI3

Stable Identifier
R-HSA-5610746
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Hyperphosphorylated GLI3 binds directly with beta-TrCP though at least three independent domains and is polyubiquitinated at lysines 773, 778, 784 and 800 (Tempe et al, 2006). After ubiquitination, GLI3 is processed to the truncated repressor form by the proteasome (Tempe et al, 2006; Wang and Li, 2006)

Literature References
PubMed ID Title Journal Year
16371461 Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing

Wang, B, Li, Y

Proc. Natl. Acad. Sci. U.S.A. 2006
16705181 Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP

Tempe, D, Casas, M, Karaz, S, Blanchet-Tournier, MF, Concordet, JP

Mol Cell Biol 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of BTRC:CUL1:RBX1:SKP1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created