Reactome: A Curated Pathway Database

SCF(beta-TrCP) ubiquitinates p-GLI3

Stable Identifier
R-HSA-5610746
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Hyperphosphorylated GLI3 binds directly with beta-TrCP though at least three independent domains and is polyubiquitinated at lysines 773, 778, 784 and 800 (Tempe et al, 2006). After ubiquitination, GLI3 is processed to the truncated repressor form by the proteasome (Tempe et al, 2006; Wang and Li, 2006)

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
ubiquitin-protein transferase activity of BTRC:CUL1:RBX1:SKP1 [cytosol] BTRC:CUL1:RBX1:SKP1 [cytosol] ubiquitin-protein transferase activity (0004842)
Orthologous Events