cAMP dissociates PKA, promoting GLI processing

Stable Identifier
R-HSA-5610749
Type
Reaction [binding]
Species
Homo sapiens
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cAMP is a known regulator of PKA activity and works by binding to the regulatory subunits and promoting dissociation of the tetramer, freeing the active catalytic subunits (reviewed in Sassone-Corsi, 2012). In the Hh pathway in the absence of ligand, cAMP levels increase in response to the recruitment of GPR161 to the ciliary base by TULP3 and the IFT-A retrograde complex (Mukhopadhyay et al, 2010; Mukhopadhyay et al, 2013). Activated PKA then initiates the phosphorylation cascade that regulates processing and/or degradation of the GLI proteins (reviewed in Briscoe and Therond, 2013; Mukhopadhyay and Rohatgi, 2014).

Literature References
PubMed ID Title Journal Year
23332756 The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling

Mukhopadhyay, S, Wen, X, Ratti, N, Loktev, A, Rangell, L, Scales, SJ, Jackson, PK

Cell 2013
23209152 The cyclic AMP pathway

Sassone-Corsi, P

Cold Spring Harb Perspect Biol 2012
20889716 TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

Mukhopadhyay, S, Wen, X, Chih, B, Nelson, CD, Lane, WS, Scales, SJ, Jackson, PK

Genes Dev. 2010
24845016 G-protein-coupled receptors, Hedgehog signaling and primary cilia

Mukhopadhyay, S, Rohatgi, R

Semin. Cell Dev. Biol. 2014
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