Reactome | cAMP dissociates PKA, promoting GLI processing

cAMP dissociates PKA, promoting GLI processing

Stable Identifier

R-HSA-5610749

Type

Reaction [binding]

Species

Homo sapiens

Compartment

ciliary base

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cAMP dissociates PKA, promoting GLI processing

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cAMP is a known regulator of PKA activity and works by binding to the regulatory subunits and promoting dissociation of the tetramer, freeing the active catalytic subunits (reviewed in Sassone-Corsi, 2012). In the Hh pathway in the absence of ligand, cAMP levels increase in response to the recruitment of GPR161 to the ciliary base by TULP3 and the IFT-A retrograde complex (Mukhopadhyay et al, 2010; Mukhopadhyay et al, 2013). Activated PKA then initiates the phosphorylation cascade that regulates processing and/or degradation of the GLI proteins (reviewed in Briscoe and Therond, 2013; Mukhopadhyay and Rohatgi, 2014).

Literature References

PubMed ID	Title	Journal	Year
23332756	The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling Mukhopadhyay, S, Wen, X, Ratti, N, Loktev, A, Rangell, L, Scales, SJ, Jackson, PK	Cell	2013
23209152	The cyclic AMP pathway Sassone-Corsi, P	Cold Spring Harb Perspect Biol	2012
20889716	TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia Mukhopadhyay, S, Wen, X, Chih, B, Nelson, CD, Lane, WS, Scales, SJ, Jackson, PK	Genes Dev.	2010
24845016	G-protein-coupled receptors, Hedgehog signaling and primary cilia Mukhopadhyay, S, Rohatgi, R	Semin. Cell Dev. Biol.	2014