GLI3R translocates to the nucleus

Stable Identifier
Reaction [omitted]
Homo sapiens
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After processing by the proteasome, the truncated GLI3 translocates into the nucleus where it acts as the primary repressor for Hh-responsive genes (reviewed in Briscoe and Therond, 2013). Based on sequence comparisons with Ci and GLI1, GLI3 is predicted to have a bipartite NLS signal near the zinc finger domain, and import to the nucleus may be mediated by Importin alpha3, although the details remain to be worked out (reviewed in Hatayama and Aruga, 2012).

Literature References
PubMed ID Title Journal Year
23719536 The mechanisms of Hedgehog signalling and its roles in development and disease

Briscoe, J, Thérond, PP

Nat. Rev. Mol. Cell Biol. 2013
22391300 Gli protein nuclear localization signal

Hatayama, M, Aruga, J

Vitam. Horm. 2012
Participant Of
Orthologous Events
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