Reactome | GLI3R translocates to the nucleus

GLI3R translocates to the nucleus

Stable Identifier

R-HSA-5610752

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

After processing by the proteasome, the truncated GLI3 translocates into the nucleus where it acts as the primary repressor for Hh-responsive genes (reviewed in Briscoe and Therond, 2013). Based on sequence comparisons with Ci and GLI1, GLI3 is predicted to have a bipartite NLS signal near the zinc finger domain, and import to the nucleus may be mediated by Importin alpha3, although the details remain to be worked out (reviewed in Hatayama and Aruga, 2012).

Literature References

PubMed ID	Title	Journal	Year
23719536	The mechanisms of Hedgehog signalling and its roles in development and disease Briscoe, J, Thérond, PP	Nat. Rev. Mol. Cell Biol.	2013
22391300	Gli protein nuclear localization signal Hatayama, M, Aruga, J	Vitam. Horm.	2012