Reactome: A Curated Pathway Database

GLI2 is degraded by the proteasome

Stable Identifier
R-HSA-5610757
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

After being ubiquitinated, the bulk of GLI2 is fully degraded by the proteasome; a small fraction of GLI2 may be converted to the repressor form after ubiquitination (Pan et al, 2006; Pan and Wang, 2007).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
endopeptidase activity of 26S proteasome [cytosol] 26S proteasome [cytosol] endopeptidase activity (0004175)
Inferred From