Reactome: A Curated Pathway Database

GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP

Stable Identifier
R-HSA-5610758
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In the absence of Hh signal, GLI1 is degraded by the proteasome. Degradation depends on GLI1 ubiquitination by SCF(beta-TrCP) and by the E3 ligase ITCH (Huntzicker et al, 2006; di Marcotullio et al, 2006, 2011).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
endopeptidase activity of 26S proteasome [cytosol] 26S proteasome [cytosol] endopeptidase activity (0004175)
Orthologous Events