Reactome | GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP

GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP

Stable Identifier

R-HSA-5610758

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

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GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP

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In the absence of Hh signal, GLI1 is degraded by the proteasome. Degradation depends on GLI1 ubiquitination by SCF(beta-TrCP) and by the E3 ligase ITCH (Huntzicker et al, 2006; di Marcotullio et al, 2006, 2011).

Literature References

PubMed ID	Title	Journal	Year
17115028	Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination Di Marcotullio, L, Ferretti, E, Greco, A, De Smaele, E, Po, A, Sico, MA, Alimandi, M, Giannini, G, Maroder, M, Screpanti, I, Gulino, A	Nat. Cell Biol.	2006
16421275	Dual degradation signals control Gli protein stability and tumor formation Huntzicker, EG, Estay, IS, Zhen, H, Lokteva, LA, Jackson, PK, Oro, AE	Genes Dev.	2006
20818436	Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal Di Marcotullio, L, Greco, A, Mazzà, D, Canettieri, G, Pietrosanti, L, Infante, P, Coni, S, Moretti, M, De Smaele, E, Ferretti, E, Screpanti, I, Gulino, A	Oncogene	2011