GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP

Stable Identifier
R-HSA-5610758
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
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Summation

In the absence of Hh signal, GLI1 is degraded by the proteasome. Degradation depends on GLI1 ubiquitination by SCF(beta-TrCP) and by the E3 ligase ITCH (Huntzicker et al, 2006; di Marcotullio et al, 2006, 2011).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
26S proteasome [cytosol]
Activity
endopeptidase activity (0004175)
Orthologous Events
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