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GLI1 is degraded by the proteasome after ubiquitination by ITCH

Stable Identifier
R-HSA-5610760
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In the absence of Hh signal, GLI1 is degraded by the proteasome. Degradation depends on GLI1 ubiquitination by SCF(beta-TrCP) and by the E3 ligase ITCH (Huntzicker et al, 2006; di Marcotullio et al, 2006, 2011).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events