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FHL2 [nucleoplasm]
Stable Identifier
R-HSA-561161
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Four and a half LIM domains protein 2, FHL2_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P32780 GTF2H1
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of FHL2 (Homo sapiens)
FHL2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14192 FHL2
Gene Names
FHL2, DRAL, SLIM3
Chain
chain:1-279
Reference Genes
BioGPS Gene:2274 FHL2
COSMIC (genes):FHL2 FHL2
CTD Gene:2274 FHL2
dbSNP Gene:2274 FHL2
ENSEMBL:ENSG00000115641 FHL2
ENSEMBL_homo_sapiens_GENE:ENSG00000115641.19 FHL2
HGNC:3703 FHL2
KEGG Gene (Homo sapiens):2274 FHL2
Monarch:2274 FHL2
NCBI Gene:2274 FHL2
OMIM:602633 FHL2
UCSC:Q14192 FHL2
Reference Transcript
RefSeq:NM_001318894.1 FHL2
RefSeq:NM_001039492.2 FHL2
RefSeq:NM_001318895.1 FHL2
RefSeq:NM_001318896.1 FHL2
RefSeq:NM_001318897.1 FHL2
RefSeq:NM_201555.1 FHL2
RefSeq:NM_001450.3 FHL2
RefSeq:NM_201557.3 FHL2
RefSeq:XM_011510798.2 FHL2
Other Identifiers
11741105_a_at
11741106_x_at
11756134_a_at
16901393
202949_PM_s_at
202949_s_at
2274
2568688
2568689
2568690
2568691
2568692
2568693
2568694
2568695
2568697
2568698
2568700
2568703
2568718
2568721
2568725
2568726
2568727
2568728
2568729
2568730
2568731
2568745
2568746
38422_s_at
8054377
A_23_P108751
A_33_P3362321
A_33_P3362326
GE473731
GE61139
GO:0000122
GO:0001649
GO:0003712
GO:0003714
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005925
GO:0006351
GO:0006355
GO:0006357
GO:0008134
GO:0009725
GO:0012501
GO:0023052
GO:0030018
GO:0030154
GO:0042802
GO:0043066
GO:0043226
GO:0043425
GO:0046872
GO:0048856
GO:0055014
GO:0055015
GO:0060347
GO:0070885
GO:0140110
HMNXSV003012326
HMNXSV003015983
ILMN_1668411
ILMN_1678643
ILMN_2265783
ILMN_2355831
L42176_at
PH_hs_0000884
g4503722_3p_a_at
Participates
as an output of
Expression of FHL2 (Homo sapiens)
Cross References
RefSeq
NP_963851.2
,
NP_001305826.1
,
NP_001305824.1
,
XP_011509100.1
,
NP_963849.1
,
NP_001034581.1
,
NP_001441.4
,
NP_001305825.1
,
NP_001305823.1
OpenTargets
ENSG00000115641
HPA
ENSG00000115641-FHL2
GeneCards
Q14192
Ensembl
ENST00000409177
,
ENST00000358129
,
ENST00000408995
,
ENSP00000344266
,
ENSP00000386665
,
ENSP00000386633
,
ENSP00000386892
,
ENSP00000433567
,
ENST00000409807
,
ENST00000393352
,
ENSP00000322909
,
ENSP00000377021
,
ENST00000344213
,
ENST00000393353
,
ENSP00000377020
,
ENSG00000115641
,
ENST00000530340
,
ENSP00000350846
,
ENST00000322142
PRO
Q14192
Pharos - Targets
Q14192
Orphanet
17363
PDB
1X4K
,
2MIU
,
2D8Z
,
1X4L
Interactors (155)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48380 RFX3
0.904
12
UniProt:Q9UBI6 GNG12
1
GNG12 [plasma membrane]
(R-HSA-164367)
0.83
11
UniProt:Q53HC0 CCD92
0.781
10
UniProt:Q9Y5P3 RAI2
0.781
7
UniProt:P14923 JUP
6
JUP [cytosol]
(R-HSA-201598)
JUP [cornified envelope]
(R-HSA-8847739)
JUP [specific granule lumen]
(R-HSA-6799534)
JUP [extracellular region]
(R-HSA-6806309)
JUP [ficolin-1-rich granule lumen]
(R-HSA-6801028)
JUP [plasma membrane]
(R-HSA-437260)
0.781
7
UniProt:Q9NPI6 DCP1A
1
DCP1A [cytosol]
(R-HSA-430043)
0.781
10
UniProt:Q8N9N5 BANP
1
BANP [nucleoplasm]
(R-HSA-3221973)
0.743
7
UniProt:Q9NYN1 RASLC
0.742
6
UniProt:Q9NTW7 ZF64B
0.742
8
UniProt:P52739-2 ZNF131
0.718
6
UniProt:Q9H2G9 BLZF1
1
BLZF1 [Golgi membrane]
(R-HSA-2422372)
0.718
10
UniProt:Q9BZQ8 NIBA1
0.718
6
UniProt:Q63ZY3 KANK2
0.718
6
UniProt:Q8N9N5-2 BANP
0.718
6
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.715
6
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.683
4
UniProt:O75398 DEAF1
0.675
4
UniProt:Q02535 ID3
1
ID3 [nucleoplasm]
(R-HSA-9613379)
0.666
4
UniProt:P52747 ZNF143
1
ZNF143 [nucleoplasm]
(R-HSA-83837)
0.666
4
UniProt:Q16656 NRF1
1
NRF1 [nucleoplasm]
(R-HSA-1592205)
0.666
5
UniProt:Q8IYX7 SAXO1
0.666
4
UniProt:Q2TAL8 QRIC1
0.666
5
UniProt:P05814 CSN2
1
CSN2 [extracellular region]
(R-HSA-1254293)
0.666
4
UniProt:Q02086 SP2
0.666
4
UniProt:Q49A26 GLYR1
0.666
4
UniProt:Q96BD5 PHF21A
1
PHF21A [nucleoplasm]
(R-HSA-996754)
0.666
5
UniProt:P36508 ZNF76
0.666
4
UniProt:Q12772 SREBF2
5
SREBF2(1-1141) [Golgi membrane]
(R-HSA-1655747)
SREBF2(1-522) [Golgi membrane]
(R-HSA-1655752)
SREBF2(1-484) [cytosol]
(R-HSA-1655723)
SREBF2(1-1141) [endoplasmic reticulum membrane]
(R-HSA-1655733)
SREBF2(1-484) [nucleoplasm]
(R-HSA-1655745)
0.666
5
UniProt:P55347 PKNOX1
1
PKNOX1 [nucleoplasm]
(R-HSA-5617496)
0.666
5
UniProt:Q0VD86 INCA1
0.666
5
UniProt:Q9Y4X4 KLF12
0.666
5
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.659
10
UniProt:Q13492 PICALM
3
PICALM [cytosol]
(R-HSA-8867593)
PICALM [cytoplasmic vesicle membrane]
(R-HSA-429812)
PICALM [Golgi membrane]
(R-HSA-434341)
0.645
8
UniProt:Q12778 FOXO1
5
p-S218-FOXO1 [nucleoplasm]
(R-HSA-5692651)
Ac-K245,K248,K265-FOXO1 [nucleoplasm]
(R-HSA-9626942)
FOXO1 [nucleoplasm]
(R-HSA-199300)
p-T24,S256,S319-FOXO1 [nucleoplasm]
(R-HSA-199306)
p-T24,S256,S319-FOXO1 [cytosol]
(R-HSA-211158)
0.639
8
UniProt:Q9C0C2 TNKS1BP1
1
TNKS1BP1 [cytosol]
(R-HSA-430011)
0.623
8
UniProt:B4DE54 B4DE54
0.601
4
UniProt:P49810 PSEN2
2
PSEN2(1-297) [plasma membrane]
(R-HSA-201599)
PSEN2(298-448) [plasma membrane]
(R-HSA-9013329)
0.593
3
UniProt:P51610-1 HCFC1
0.593
5
UniProt:Q06546 GABPA
1
GABPA [nucleoplasm]
(R-HSA-1592206)
0.59
2
UniProt:P08047 SP1
1
SP1 [nucleoplasm]
(R-HSA-1592223)
0.59
3
UniProt:A1E959 ODAM
1
ODAM [extracellular region]
(R-HSA-977149)
0.564
2
UniProt:P98182 ZNF200
1
ZNF200 [nucleoplasm]
(R-HSA-974991)
0.556
3
UniProt:Q96JP2 MY15B
0.556
5
UniProt:O95863 SNAI1
1
SNAI1 [nucleoplasm]
(R-HSA-2980903)
0.556
3
UniProt:O43699 SIGLEC6
1
SIGLEC6 [plasma membrane]
(R-HSA-197708)
0.556
3
UniProt:Q8IVT2 MISP
0.556
3
UniProt:P50150 GNG4
1
GNG4 [plasma membrane]
(R-HSA-164350)
0.556
3
UniProt:O14639-4 ABLIM1
0.556
3
UniProt:Q53TS8 CTSRT
0.556
3
UniProt:Q7Z5V6-2 SAXO4
0.556
3
UniProt:Q3KP44 ANR55
0.556
3
UniProt:Q5SW96 LDLRAP1
2
LDLRAP1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869097)
LDLRAP1 [plasma membrane]
(R-HSA-171143)
0.556
3
IntAct:EBI-22313194 CCSB ORF ID
0.556
3
UniProt:E9PSE9 E9PSE9
0.556
3
UniProt:O15535 ZSC9
0.556
3
UniProt:Q6ZNG0 ZNF620
1
ZNF620 [nucleoplasm]
(R-HSA-2127603)
0.556
3
UniProt:Q8IZP0-5 ABI1
0.556
3
UniProt:Q49A26-4 GLYR1
0.556
3
UniProt:O43189 PHF1
1
PHF1 [nucleoplasm]
(R-HSA-5084105)
0.556
3
UniProt:Q9BWG6 SCNM1
0.556
3
UniProt:Q9NQX0 PRDM6
0.556
3
UniProt:O75155 CAND2
0.556
3
UniProt:O75031 HSF2B
0.556
3
IntAct:EBI-22384931 CCSB ORF ID
0.556
3
UniProt:Q49A12 Q49A12
0.556
3
UniProt:Q8TAG6 VEXIN
0.556
3
UniProt:Q5T5P2-6 KIAA1217
0.556
3
UniProt:O94993 SOX30
0.556
3
UniProt:Q9H1P6 CMIP1
0.556
3
IntAct:EBI-22432104 CCSB ORF ID
0.556
3
UniProt:Q9BRR9 ARHGAP9
3
ARHGAP9 [cytosol]
(R-HSA-2976572)
ARHGAP9 [extracellular region]
(R-HSA-6806529)
ARHGAP9 [secretory granule lumen]
(R-HSA-6804973)
0.556
3
UniProt:P78424 PO6F2
0.556
3
UniProt:Q9UKD1 GMEB2
0.556
3
UniProt:Q86VK4-3 ZNF410
0.556
3
IntAct:EBI-22381398 CCSB ORF ID
0.556
3
UniProt:Q6MZQ0 PRR5L
0.556
3
UniProt:Q9H8W3 F204A
0.556
3
UniProt:Q86UV6-2 TRIM74
0.556
3
UniProt:Q5T3J3 LRIF1
0.556
3
UniProt:P25490 YY1
1
YY1 [nucleoplasm]
(R-HSA-4086091)
0.556
5
UniProt:Q8ND83 SLAI1
0.556
3
UniProt:Q658L1 SAXO2
0.556
3
UniProt:Q9NQV5 PRD11
0.556
3
UniProt:Q13422-7 IKZF1
0.556
3
UniProt:Q9UMQ3 BARX2
0.556
3
UniProt:Q96KN3 PKNX2
0.556
3
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.556
3
UniProt:W5RWE1 W5RWE1
0.556
3
UniProt:Q5T749 KPRP
1
KPRP [cytosol]
(R-HSA-9839614)
0.556
3
UniProt:Q96D03 DDT4L
0.556
3
IntAct:EBI-22343137 CCSB ORF ID
0.556
3
UniProt:Q5VZL5 ZMYM4
0.556
3
UniProt:Q6IS01 Q6IS01
0.556
3
UniProt:Q6F5E7 TR3N
0.556
3
UniProt:P32780 GTF2H1
1
GTF2H1 [nucleoplasm]
(R-HSA-65912)
0.556
3
UniProt:Q8WWY6 MB3L1
0.556
3
UniProt:Q9NQ31 AKIP1
0.556
3
UniProt:Q16656-4 NRF1
0.556
3
UniProt:A0PJW8 DAPL1
0.556
3
UniProt:Q02086-2 SP2
0.556
3
UniProt:Q9C004 SPY4
0.556
3
UniProt:P80217-2 IFI35
0.556
5
UniProt:Q8TDR4 TCP1L
0.556
3
UniProt:Q86UW9 DTX2
1
DTX2 [cytosol]
(R-HSA-1604436)
0.556
6
UniProt:Q9UJ55 MAGL2
0.556
3
UniProt:Q14005-2 Q140052
0.556
3
UniProt:A0A0S2Z5G4 A0A0S2Z5G4
0.556
3
UniProt:P33176 KIF5B
3
KIF5B [cytosol]
(R-HSA-265181)
KIF5B(2-575)-p-7Y-ALK(1063-1620) fusion [cytosol]
(R-HSA-9711937)
KIF5B(2-575)-ALK(1063-1620) fusion [cytosol]
(R-HSA-9711964)
0.556
3
UniProt:P13984 GTF2F2
1
GTF2F2 [nucleoplasm]
(R-HSA-65567)
0.556
3
UniProt:P17027 ZNF23
1
ZNF23 [nucleoplasm]
(R-HSA-1027395)
0.556
3
UniProt:A2BDD9 A2BDD9
0.556
3
UniProt:Q7Z3K3 POGZ
0.556
3
UniProt:Q0D2K3 RIPP1
0.556
3
UniProt:Q8N9N5-7 BANP
0.556
3
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.556
3
UniProt:Q9NYA3 GOG6A
0.556
3
UniProt:Q9NQ94 A1CF
1
A1CF [nucleoplasm]
(R-HSA-3211440)
0.556
3
UniProt:Q8WXI9 GATAD2B
1
GATAD2B [nucleoplasm]
(R-HSA-3702079)
0.556
3
UniProt:Q8N720 ZNF655
1
ZNF655 [nucleoplasm]
(R-HSA-2127575)
0.556
3
UniProt:Q8TAU3 ZNF417
1
ZNF417 [nucleoplasm]
(R-HSA-1247539)
0.556
3
UniProt:Q7L5A3 ATOSB
0.556
3
UniProt:P52739 ZNF131
2
monoSUMO1-K601-ZNF131 [nucleoplasm]
(R-HSA-3296152)
ZNF131 [nucleoplasm]
(R-HSA-3296168)
0.547
3
UniProt:Q9NYA1 SPHK1
4
SPHK1 [nucleoplasm]
(R-HSA-9836616)
p-S225-SPHK1 [nucleoplasm]
(R-HSA-9836613)
p-S225-SPHK1 [cytosol]
(R-HSA-5218716)
SPHK1 [cytosol]
(R-HSA-391267)
0.543
7
UniProt:P28908 TNFRSF8
1
TNFRSF8 [plasma membrane]
(R-HSA-5668758)
0.527
2
UniProt:Q13011 ECH1
3
ECH1 [mitochondrial matrix]
(R-HSA-9838037)
ECH1(1-328) [peroxisomal matrix]
(R-HSA-9033140)
ECH1(1-328) [cytosol]
(R-HSA-9033152)
0.527
2
UniProt:P68104 EEF1A1
7
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [lysosomal membrane]
(R-HSA-9626022)
0.527
3
UniProt:Q9NZN8 CNOT2
1
CNOT2 [cytosol]
(R-HSA-429902)
0.527
3
UniProt:Q8WVH0 CPLX3
0.527
2
UniProt:A2VCK2 DCD2B
0.527
2
UniProt:Q7Z6M3 MILR1
0.527
2
UniProt:Q96FX7 TRMT61A
1
TRMT61A [nucleoplasm]
(R-HSA-6783477)
0.527
2
UniProt:Q9BRK5 CAB45
0.527
2
UniProt:P60321 NANO2
0.527
2
UniProt:A5YKK6 CNOT1
1
CNOT1 [cytosol]
(R-HSA-429892)
0.527
3
UniProt:P47755 CAPZA2
2
CAPZA2 [cytosol]
(R-HSA-879448)
CAPZA2(265-276) [extracellular region]
(R-HSA-879417)
0.527
3
UniProt:Q8TEW6 DOK4
1
DOK4 [cytosol]
(R-HSA-8847701)
0.527
2
UniProt:Q9H410 DSN1
3
DSN1 [cytosol]
(R-HSA-375308)
DSN1 [azurophil granule lumen]
(R-HSA-6799218)
DSN1 [extracellular region]
(R-HSA-6806228)
0.527
2
UniProt:Q9UEU0 VTI1B
2
VTI1B [extracellular region]
(R-HSA-8862983)
VTI1B [platelet alpha granule lumen]
(R-HSA-8862964)
0.527
2
UniProt:P50616 TOB1
0.527
2
UniProt:Q9H3Q1 CDC42EP4
1
CDC42EP4 [cytosol]
(R-HSA-9691381)
0.527
2
UniProt:Q9UKZ1 CNOT11
1
CNOT11 [cytosol]
(R-HSA-429981)
0.527
3
UniProt:Q8N443 RIBC1
0.527
2
UniProt:P47756 CAPZB
1
CAPZB [cytosol]
(R-HSA-879409)
0.527
2
UniProt:P22415 USF1
2
USF1 [nucleoplasm]
(R-HSA-9023562)
pT153 USF1 [nucleoplasm]
(R-HSA-9855887)
0.527
3
UniProt:Q6NZI2 PTRF
2
PTRF [nucleoplasm]
(R-HSA-74981)
CAVIN1 [plasma membrane]
(R-HSA-9714278)
0.527
2
UniProt:Q9Y2G2 CARD8
1
CARD8 [cytosol]
(R-HSA-6805447)
0.508
2
UniProt:Q9ERP3 TRI54
0.508
2
UniProt:Q9UBZ9 REV1
1
REV1 [nucleoplasm]
(R-HSA-3006726)
0.508
2
UniProt:P05556 ITGB1
2
ITGB1 [endosome membrane]
(R-HSA-9611157)
ITGB1 [plasma membrane]
(R-HSA-57596)
0.508
2
UniProt:P26006-1 ITGA3
0.508
2
UniProt:Q9H9D4 ZN408
0.508
3
UniProt:Q13683 ITGA7
1
ITGA7(34-1181) [plasma membrane]
(R-HSA-215940)
0.508
2
UniProt:P10275 AR
4
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
AR [nucleoplasm]
(R-HSA-446174)
AR [cytosol]
(R-HSA-5618082)
0.508
2
UniProt:P18847 ATF3
1
ATF3 [nucleoplasm]
(R-HSA-535543)
0.508
3
UniProt:Q13643 FHL3
0.454
2
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